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Twenty-two patients with advanced primary bladder cancer with metastatic lesions were treated with a combination of 5-FU, vincristine, bleomycin, mitomycin, and methotrexate. Complete and partial responses were achieved in two (9%) and five (23%) patients, respectively. The overall response rate was 32%. The major toxic effects were myelosuppression and mild gastrointestinal symptoms.
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