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In vitro exposure of mast but not of other cells of rat peritoneal fluid to epinephrine leads, within 1 min, to progressing levels of histamine in both fluid and sedimentable phases of the incubates, which present no increase in their free/total histamine ratio. Histamine increase was blocked by alpha-fluoromethyl histidine (alpha FMH), acting after a significant lag period. When compared with controls under the electron microscope, epinephrine-treated mast cells show less electron-dense, swollen intracellular granules, apparent maintenance of cell membrane continuity and an apparent decrease of peripheral finger-like projections. Histamine accumulation by epinephrine-treated mast cells may be the result of an enhanced ability of pre-formed mast cell histidine decarboxylase to attack its cell-borne substrate, consequent to an unfolding of the cell membrane during cell tumefaction evoked by epinephrine.
A M Rothschild, and
E L Gomes
October 1984,
Experientia,
A M Rothschild, and
E L Gomes
April 1969,
Biochemical pharmacology,
A M Rothschild, and
E L Gomes
August 1956,
The American journal of physiology,
A M Rothschild, and
E L Gomes
April 1982,
Agents and actions,
A M Rothschild, and
E L Gomes
April 1988,
European journal of pharmacology,
A M Rothschild, and
E L Gomes
December 1981,
European journal of pharmacology,
A M Rothschild, and
E L Gomes
April 1986,
Environmental health perspectives,
A M Rothschild, and
E L Gomes
November 2001,
Biological & pharmaceutical bulletin,
A M Rothschild, and
E L Gomes
April 1986,
Agents and actions,
A M Rothschild, and
E L Gomes
June 1986,
Biochemical pharmacology,
