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Relationships between pretreatment neurotransmitter metabolite levels and response to imipramine and amitriptyline were studied in 104 depressed patients. Normal values for urinary norepinephrine and low values for urinary MHPG were associated with greater incidence of drug response in bipolar, but not unipolar, patients. For unipolar, but not bipolar, patients low CSF 5-HIAA and high urinary metanephrine values were associated with a greater incidence of drug response. These data indicate that the pretreatment functional state of catecholamine and serotonin systems is associated with type of response to drug treatment. The authors present hypotheses about the association of alterations in serotonin and norepinephrine systems and definable subtypes of depression.
J W Maas, and
S H Koslow, and
M M Katz, and
C L Bowden, and
R L Gibbons, and
P E Stokes, and
E Robins, and
J M Davis
March 1985,
Clinical pharmacology and therapeutics,
J W Maas, and
S H Koslow, and
M M Katz, and
C L Bowden, and
R L Gibbons, and
P E Stokes, and
E Robins, and
J M Davis
January 1982,
Journal of cardiovascular pharmacology,
J W Maas, and
S H Koslow, and
M M Katz, and
C L Bowden, and
R L Gibbons, and
P E Stokes, and
E Robins, and
J M Davis
March 1976,
The Australian and New Zealand journal of psychiatry,
J W Maas, and
S H Koslow, and
M M Katz, and
C L Bowden, and
R L Gibbons, and
P E Stokes, and
E Robins, and
J M Davis
March 1988,
American family physician,
J W Maas, and
S H Koslow, and
M M Katz, and
C L Bowden, and
R L Gibbons, and
P E Stokes, and
E Robins, and
J M Davis
December 1985,
The Journal of clinical psychiatry,
J W Maas, and
S H Koslow, and
M M Katz, and
C L Bowden, and
R L Gibbons, and
P E Stokes, and
E Robins, and
J M Davis
January 1976,
Postgraduate medical journal,
J W Maas, and
S H Koslow, and
M M Katz, and
C L Bowden, and
R L Gibbons, and
P E Stokes, and
E Robins, and
J M Davis
January 1977,
Clinical toxicology,
J W Maas, and
S H Koslow, and
M M Katz, and
C L Bowden, and
R L Gibbons, and
P E Stokes, and
E Robins, and
J M Davis
November 1971,
Diseases of the nervous system,
J W Maas, and
S H Koslow, and
M M Katz, and
C L Bowden, and
R L Gibbons, and
P E Stokes, and
E Robins, and
J M Davis
February 1975,
British journal of clinical pharmacology,
J W Maas, and
S H Koslow, and
M M Katz, and
C L Bowden, and
R L Gibbons, and
P E Stokes, and
E Robins, and
J M Davis
December 1980,
Neuropharmacology,
