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Neoadjuvant induction chemotherapy with cisplatin, methotrexate, and bleomycin appears to improve the results of treatment of advanced stage IV head and neck cancer, compared with results in historical control subjects. Patients treated with induction chemotherapy and radiation therapy had a 29 percent overall survival rate at 3 years, which represents approximately a twofold improvement in the survival rate. Patients who were treated with chemotherapy and radiation therapy followed by surgery had more than a threefold increase in the survival rate (49 percent at 3 years), compared with historical data from our institution and elsewhere for such patients [9-11]. Distant metastases developed in 25 percent of the patients, and it thus appears that long-term, effective consolidation and maintenance chemotherapy [12,13] need to be developed for patients who receive combination therapy before surgery for head and neck cancer.
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B F Rush, and
G J Hill, and
M Ohanian, and
S Raina, and
K S Dasmahapatra, and
N K Cheung
January 1984,
Head & neck surgery,
M A Mohit-Tabatabai, and
B F Rush, and
G J Hill, and
M Ohanian, and
S Raina, and
K S Dasmahapatra, and
N K Cheung
September 1989,
Journal of the South Carolina Medical Association (1975),
M A Mohit-Tabatabai, and
B F Rush, and
G J Hill, and
M Ohanian, and
S Raina, and
K S Dasmahapatra, and
N K Cheung
January 1984,
Head & neck surgery,
M A Mohit-Tabatabai, and
B F Rush, and
G J Hill, and
M Ohanian, and
S Raina, and
K S Dasmahapatra, and
N K Cheung
October 2010,
Annals of oncology : official journal of the European Society for Medical Oncology,
M A Mohit-Tabatabai, and
B F Rush, and
G J Hill, and
M Ohanian, and
S Raina, and
K S Dasmahapatra, and
N K Cheung
April 1984,
The Laryngoscope,
M A Mohit-Tabatabai, and
B F Rush, and
G J Hill, and
M Ohanian, and
S Raina, and
K S Dasmahapatra, and
N K Cheung
January 1984,
Head & neck surgery,
M A Mohit-Tabatabai, and
B F Rush, and
G J Hill, and
M Ohanian, and
S Raina, and
K S Dasmahapatra, and
N K Cheung
November 2001,
Gan to kagaku ryoho. Cancer & chemotherapy,
M A Mohit-Tabatabai, and
B F Rush, and
G J Hill, and
M Ohanian, and
S Raina, and
K S Dasmahapatra, and
N K Cheung
May 2003,
The Veterinary clinics of North America. Small animal practice,
M A Mohit-Tabatabai, and
B F Rush, and
G J Hill, and
M Ohanian, and
S Raina, and
K S Dasmahapatra, and
N K Cheung
January 1984,
Head & neck surgery,
M A Mohit-Tabatabai, and
B F Rush, and
G J Hill, and
M Ohanian, and
S Raina, and
K S Dasmahapatra, and
N K Cheung
September 1988,
Radiology,
