-transparent.png){kind=logo}
Daily subcutaneous administration for 3 months of the potent LHRH agonist (D-Ser(TBU)6, des-Gly-NH2(10] LHRH ethylamide (25 micrograms) to adult dogs having spontaneous benign prostate hyperplasia (BPH) causes a marked inhibition of testicular androstenedione and testosterone secretion. This inhibition of delta 4-androgen secretion is accompanied by a decrease of testicular progestin precursors and 5 alpha-androgen metabolites, thus suggesting that, in dog, the loss of testicular steroidogenic activity, induced by the administration of an LHRH agonist, is due to a total inhibition of testicular steroidogenesis. In plasma, the concentration of both testosterone and dihydrotestosterone is also markedly depressed while androstane-3 alpha, 17 beta-diol levels remain unchanged. Measurement of prostatic steroid content has shown that administration of the LHRH agonist as well as castration is associated with a marked decrease in androstenedione, testosterone, and dihydrotestosterone levels in prostate while there is a small inhibition of androst-5-ene-3 beta, 17 beta-diol, androstane-3 beta, 17 beta-diol, dehydroepiandrosterone, and estrone concentrations in this tissue. The present data show that treatment with an LHRH agonist in the dog causes a marked inhibition of testicular steroid secretion similar to the one observed in adult men, and suggest that steroids from adrenal origin may also be involved in prostatic function.
Y Tremblay, and
A Bélanger, and
F Labrie, and
G Frenette, and
J Y Dubé, and
R R Tremblay
June 1980,
Biology of reproduction,
Y Tremblay, and
A Bélanger, and
F Labrie, and
G Frenette, and
J Y Dubé, and
R R Tremblay
April 1980,
L'union medicale du Canada,
Y Tremblay, and
A Bélanger, and
F Labrie, and
G Frenette, and
J Y Dubé, and
R R Tremblay
December 1987,
International journal of andrology,
Y Tremblay, and
A Bélanger, and
F Labrie, and
G Frenette, and
J Y Dubé, and
R R Tremblay
February 1980,
Journal of steroid biochemistry,
Y Tremblay, and
A Bélanger, and
F Labrie, and
G Frenette, and
J Y Dubé, and
R R Tremblay
November 1984,
Journal of reproduction and fertility,
Y Tremblay, and
A Bélanger, and
F Labrie, and
G Frenette, and
J Y Dubé, and
R R Tremblay
June 1984,
International journal of andrology,
Y Tremblay, and
A Bélanger, and
F Labrie, and
G Frenette, and
J Y Dubé, and
R R Tremblay
December 1982,
Steroids,
Y Tremblay, and
A Bélanger, and
F Labrie, and
G Frenette, and
J Y Dubé, and
R R Tremblay
May 1992,
The Journal of endocrinology,
Y Tremblay, and
A Bélanger, and
F Labrie, and
G Frenette, and
J Y Dubé, and
R R Tremblay
November 2008,
Archives of toxicology,
Y Tremblay, and
A Bélanger, and
F Labrie, and
G Frenette, and
J Y Dubé, and
R R Tremblay
January 1992,
The Journal of urology,
