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Cutaneous T-cell lymphomas (CTCL) are neoplasias of mature T-cells and comprise Sezary syndrome, mycosis fungoides and some cases of lymphomatoid papulosis. Clinically this group of disorders differ from the more aggressive neoplasias of mature T-cells known as adult T-cell leukemia/lymphoma and T-cell lymphosarcoma leukemia which are associated with human T-cell leukemia virus (HTLV). We have found that of 68 patients from Denmark with CTCL ten were positive for HTLV antibodies and that the neoplastic T-cells from skin specimens in seven of eight HTLV-antibody positive patients studied by DNA flow cytometry exhibit DNA aneuploidy. Either one or two hyperdiploid cell clones were present. Aneuploidy was found in two patients with histologically verified mycosis fungoides, in four patients with histological non-diagnostic mycosis fungoides, and in one patient with lymphomatoid papulosis. The present data indicate that further seroepidemiologic survey studies of cutaneous T-cell lymphomas should include the early histological non-diagnostic stages, especially when aneuploidy is present.
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W C Saxinger, and
A Woods, and
J K Larsen, and
K Thomsen, and
R C Gallo
January 1983,
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G Lange Wantzin, and
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G Lange Wantzin, and
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R C Gallo
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G Lange Wantzin, and
W C Saxinger, and
A Woods, and
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R C Gallo
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G Lange Wantzin, and
W C Saxinger, and
A Woods, and
J K Larsen, and
K Thomsen, and
R C Gallo
September 1982,
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G Lange Wantzin, and
W C Saxinger, and
A Woods, and
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K Thomsen, and
R C Gallo
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G Lange Wantzin, and
W C Saxinger, and
A Woods, and
J K Larsen, and
K Thomsen, and
R C Gallo
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G Lange Wantzin, and
W C Saxinger, and
A Woods, and
J K Larsen, and
K Thomsen, and
R C Gallo
January 1983,
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G Lange Wantzin, and
W C Saxinger, and
A Woods, and
J K Larsen, and
K Thomsen, and
R C Gallo
January 1983,
Progress in clinical and biological research,
G Lange Wantzin, and
W C Saxinger, and
A Woods, and
J K Larsen, and
K Thomsen, and
R C Gallo
November 1994,
The Journal of experimental medicine,
