Dapsone and human polymorphonuclear leucocyte chemotaxis in dermatitis herpetiformis. 1984

B W Millar, and K J Macdonald, and T M Macleod, and E J Raffle

Polymorphonuclear leucocyte chemotaxis was investigated in 6 patients with active dermatitis herpetiformis in the untreated state and when under control with Dapsone. Control studies were undertaken in 7 healthy volunteers. No significant difference in chemotaxis was demonstrated between the active, treated and control groups. Furthermore, when Dapsone in physiological concentrations was added separately in all three groups there was no additional effect on chemotaxis. These results clearly show that polymorphonuclear leucocytes from active untreated dermatitis herpetiformis have normal chemotactic activity compared with those from the same patients in the treated state and controls. Additional Dapsone did not alter these findings.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D009504 Neutrophils Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes. LE Cells,Leukocytes, Polymorphonuclear,Polymorphonuclear Leukocytes,Polymorphonuclear Neutrophils,Neutrophil Band Cells,Band Cell, Neutrophil,Cell, LE,LE Cell,Leukocyte, Polymorphonuclear,Neutrophil,Neutrophil Band Cell,Neutrophil, Polymorphonuclear,Polymorphonuclear Leukocyte,Polymorphonuclear Neutrophil
D002634 Chemotaxis, Leukocyte The movement of leukocytes in response to a chemical concentration gradient or to products formed in an immunologic reaction. Leukotaxis,Leukocyte Chemotaxis
D003622 Dapsone A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8) Diaminodiphenylsulfone,Sulfonyldianiline,4,4'-Diaminophenyl Sulfone,Avlosulfone,DADPS,Dapsoderm-X,Dapson-Fatol,Diaphenylsulfone,Disulone,Sulfona,4,4' Diaminophenyl Sulfone,Sulfone, 4,4'-Diaminophenyl
D003874 Dermatitis Herpetiformis Rare, chronic, papulo-vesicular disease characterized by an intensely pruritic eruption consisting of various combinations of symmetrical, erythematous, papular, vesicular, or bullous lesions. The disease is strongly associated with the presence of HLA-B8 and HLA-DR3 antigens. A variety of different autoantibodies has been detected in small numbers in patients with dermatitis herpetiformis. Duhring's Disease,Duhring Disease,Disease, Duhring,Disease, Duhring's,Duhrings Disease
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

B W Millar, and K J Macdonald, and T M Macleod, and E J Raffle
January 1981, Acta dermato-venereologica,
B W Millar, and K J Macdonald, and T M Macleod, and E J Raffle
June 1955, Lancet (London, England),
B W Millar, and K J Macdonald, and T M Macleod, and E J Raffle
April 1974, The British journal of dermatology,
B W Millar, and K J Macdonald, and T M Macleod, and E J Raffle
February 1981, The British journal of dermatology,
B W Millar, and K J Macdonald, and T M Macleod, and E J Raffle
January 1999, Indian journal of dermatology, venereology and leprology,
B W Millar, and K J Macdonald, and T M Macleod, and E J Raffle
June 1955, Lancet (London, England),
B W Millar, and K J Macdonald, and T M Macleod, and E J Raffle
January 1983, The British journal of dermatology,
B W Millar, and K J Macdonald, and T M Macleod, and E J Raffle
May 2017, International journal of dermatology,
B W Millar, and K J Macdonald, and T M Macleod, and E J Raffle
February 1977, Lancet (London, England),
B W Millar, and K J Macdonald, and T M Macleod, and E J Raffle
September 1980, British journal of clinical pharmacology,
Copied contents to your clipboard!