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Serial blood samples for determination of drug levels were obtained after intravenous administration of 300 mg of cimetidine. Sixteen patients with varying degrees of renal failure were studied. There was a prolongation of drug half-life in patients with renal insufficiency compared with that in normal controls (P less than 0.001). A significant inverse relationship between the half-life and the creatinine clearance was noted (r= 0.69; P less than 0.01). The effect of hemodialysis was studied in 12 patients. Cimetidine was found to be dialyzable. This was demonstrated both by a shortening of the half-life of the drug during dialysis and by measurement of dialysance. This suggests that the dose schedule should be modified for patients with renal insufficiency and for those on hemodialysis. A single intraveno us dose of cimetidine was well tolerated by the patients. One patient developed an urticarial skin rash, believed to be allergic in nature. There was a transient, mild (but significant) rise in blood urea nitrogen and serum creatinine concentration in 5 patients with moderate renal failure.
K W Ma, and
D C Brown, and
D S Masler, and
S E Silvis
January 1980,
Acta medica Scandinavica,
K W Ma, and
D C Brown, and
D S Masler, and
S E Silvis
June 1980,
Postgraduate medical journal,
K W Ma, and
D C Brown, and
D S Masler, and
S E Silvis
October 1977,
Lancet (London, England),
K W Ma, and
D C Brown, and
D S Masler, and
S E Silvis
November 1982,
British medical journal (Clinical research ed.),
K W Ma, and
D C Brown, and
D S Masler, and
S E Silvis
March 1981,
Southern medical journal,
K W Ma, and
D C Brown, and
D S Masler, and
S E Silvis
April 1981,
Annals of internal medicine,
K W Ma, and
D C Brown, and
D S Masler, and
S E Silvis
February 1982,
Annals of internal medicine,
K W Ma, and
D C Brown, and
D S Masler, and
S E Silvis
October 1982,
British medical journal (Clinical research ed.),
K W Ma, and
D C Brown, and
D S Masler, and
S E Silvis
February 1989,
Gastroenterology,
K W Ma, and
D C Brown, and
D S Masler, and
S E Silvis
January 1991,
Nephron,
