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In a multiclinic double-blind trial, 305 patients with moderate to severe acne vulgaris were treated with oral tetracycline hydrochloride, 250 mg (N: 103), a 1% solution of clindamycin phosphate (N: 105), or placebo (N: 97) twice daily for 8 weeks. The response to treatment was evaluated by lesion counts and overall clinical improvement at 2, 4, 6, and 8 weeks. Both topical clindamycin and oral tetracycline significantly reduced papule and pustule counts compared to placebo; they were rated significantly higher than placebo on the physician's and the patient's overall evaluation at the end of the treatment period. No serious side effects were reported with any of the study medications.
D Gratton, and
G P Raymond, and
S Guertin-Larochelle, and
S W Maddin, and
C M Leneck, and
J Warner, and
J P Collins, and
P Gaudreau, and
B J Bendl
January 1983,
Journal of the American Academy of Dermatology,
D Gratton, and
G P Raymond, and
S Guertin-Larochelle, and
S W Maddin, and
C M Leneck, and
J Warner, and
J P Collins, and
P Gaudreau, and
B J Bendl
March 1983,
Journal of the American Academy of Dermatology,
D Gratton, and
G P Raymond, and
S Guertin-Larochelle, and
S W Maddin, and
C M Leneck, and
J Warner, and
J P Collins, and
P Gaudreau, and
B J Bendl
November 1980,
Journal of the American Academy of Dermatology,
D Gratton, and
G P Raymond, and
S Guertin-Larochelle, and
S W Maddin, and
C M Leneck, and
J Warner, and
J P Collins, and
P Gaudreau, and
B J Bendl
December 1998,
Journal of the American Academy of Dermatology,
D Gratton, and
G P Raymond, and
S Guertin-Larochelle, and
S W Maddin, and
C M Leneck, and
J Warner, and
J P Collins, and
P Gaudreau, and
B J Bendl
January 1984,
Scandinavian journal of infectious diseases. Supplementum,
D Gratton, and
G P Raymond, and
S Guertin-Larochelle, and
S W Maddin, and
C M Leneck, and
J Warner, and
J P Collins, and
P Gaudreau, and
B J Bendl
January 1981,
International journal of dermatology,
D Gratton, and
G P Raymond, and
S Guertin-Larochelle, and
S W Maddin, and
C M Leneck, and
J Warner, and
J P Collins, and
P Gaudreau, and
B J Bendl
January 1993,
International journal of dermatology,
D Gratton, and
G P Raymond, and
S Guertin-Larochelle, and
S W Maddin, and
C M Leneck, and
J Warner, and
J P Collins, and
P Gaudreau, and
B J Bendl
January 1977,
Cutis,
D Gratton, and
G P Raymond, and
S Guertin-Larochelle, and
S W Maddin, and
C M Leneck, and
J Warner, and
J P Collins, and
P Gaudreau, and
B J Bendl
March 1987,
The British journal of dermatology,
D Gratton, and
G P Raymond, and
S Guertin-Larochelle, and
S W Maddin, and
C M Leneck, and
J Warner, and
J P Collins, and
P Gaudreau, and
B J Bendl
November 1984,
Zeitschrift fur Hautkrankheiten,
