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This study was undertaken to determine whether a reduction in body weight in laboratory mice by regimens that appear to delay the rate of aging (i.e., food restriction and chronic dehydroepiandrosterone (DHEA) treatment), or a production of obesity by the presence of the ob (obese) gene or by gold thioglucose-induced hyperphagia alter the rate of binding of 3H-7,12-dimethylbenz(a)anthracene (3H-DMBA) to mouse skin deoxyribonucleic acid (DNA). We have found that treating A/J mice with food containing .6% DHEA for 10 weeks or reducing the food intake of non-DHEA treated mice to 60% of ad libitum fed animals significantly reduces the amount of 3H-DMBA bound to mouse skin DNA 12 hours after a topical application of the carcinogen. Conversely, A/J mice made obese by a gold thioglucose-induced hyperphagia and C57BL/6J mice with the ob mutation bind significantly increased amounts of 3H-DMBA to skin DNA when compared to their nonobese counterparts.
L L Pashko, and
A G Schwartz
December 1983,
Cancer research,
L L Pashko, and
A G Schwartz
June 1974,
Chemico-biological interactions,
L L Pashko, and
A G Schwartz
June 1988,
Cancer letters,
L L Pashko, and
A G Schwartz
February 1985,
Cancer research,
L L Pashko, and
A G Schwartz
July 1974,
Chemico-biological interactions,
L L Pashko, and
A G Schwartz
January 1993,
Chemical research in toxicology,
L L Pashko, and
A G Schwartz
May 1989,
Carcinogenesis,
L L Pashko, and
A G Schwartz
February 1967,
Cancer research,
L L Pashko, and
A G Schwartz
December 1978,
Research communications in chemical pathology and pharmacology,
L L Pashko, and
A G Schwartz
August 1978,
Journal of the National Cancer Institute,
