-transparent.png){kind=logo}
We analyzed the effects of a polycythemic substrain of Friend leukemia virus, i.e. the FLV-P virus, on splenic NK activity of DBA/2 susceptible mice. One day after virus injection a significant increase of NK activity was found, which persisted until day 10. On the other hand, 14-21 days after virus injection a marked and significant depression of activity was measured. This depression was associated with the appearance of suppressor cells able to inhibit the lytic activity of untreated splenocytes when mixed in vitro in the 4 h 51Cr-release assay. The suppressor cell population was insensitive to treatment with anti-Thy 1.2 plus complement, was adherent to Sephadex G-10 and nylon, but did not adhere to plastic, suggesting it is neither a T-cell nor a typical macrophage. The possible relevance of NK activity modulation in relation to the induction of leukemia is discussed.
G Migliorati, and
T Jezzi, and
L Frati, and
E Bonmassar, and
G B Rossi, and
E Garaci, and
C Riccardi
March 1981,
Immunogenetics,
G Migliorati, and
T Jezzi, and
L Frati, and
E Bonmassar, and
G B Rossi, and
E Garaci, and
C Riccardi
November 2004,
Brain, behavior, and immunity,
G Migliorati, and
T Jezzi, and
L Frati, and
E Bonmassar, and
G B Rossi, and
E Garaci, and
C Riccardi
January 1984,
Metabolic bone disease & related research,
G Migliorati, and
T Jezzi, and
L Frati, and
E Bonmassar, and
G B Rossi, and
E Garaci, and
C Riccardi
April 1996,
Methods (San Diego, Calif.),
G Migliorati, and
T Jezzi, and
L Frati, and
E Bonmassar, and
G B Rossi, and
E Garaci, and
C Riccardi
December 1986,
Journal of virology,
G Migliorati, and
T Jezzi, and
L Frati, and
E Bonmassar, and
G B Rossi, and
E Garaci, and
C Riccardi
September 1997,
Clinical and experimental immunology,
G Migliorati, and
T Jezzi, and
L Frati, and
E Bonmassar, and
G B Rossi, and
E Garaci, and
C Riccardi
March 2006,
Virology,
G Migliorati, and
T Jezzi, and
L Frati, and
E Bonmassar, and
G B Rossi, and
E Garaci, and
C Riccardi
April 1984,
Cellular immunology,
G Migliorati, and
T Jezzi, and
L Frati, and
E Bonmassar, and
G B Rossi, and
E Garaci, and
C Riccardi
January 1988,
Bollettino dell'Istituto sieroterapico milanese,
G Migliorati, and
T Jezzi, and
L Frati, and
E Bonmassar, and
G B Rossi, and
E Garaci, and
C Riccardi
January 1981,
Microbiology and immunology,
