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The concentrations of pregnanediol-3-glucuronide (PGD) and pregnanolone (PN) were measured in daily morning urine specimens from 66 infertile women (40 with varying degrees of endometriosis and 26 control subjects) and correlated with daily changes in basal body temperature (BBT) and with midluteal levels of serum progesterone (P). PN and BBT rose at midcycle in women with endometriosis, as expected, indicating secretion of some P at that time. However, PGD, the major endpoint of P metabolism, was delayed in its excretion. Endometrial biopsies were similarly delayed (out of phase) in women with endometriosis, and a significantly higher incidence of follicular luteinization was seen. It appears that while P secretion begins at midcycle, the bulk of P secretion is delayed, perhaps because of the process of follicular luteinization, and that a shortened functional luteal phase thus exists in women with endometriosis.
K L Cheesman, and
S D Cheesman, and
R T Chatterton, and
M R Cohen
November 1989,
Nihon Sanka Fujinka Gakkai zasshi,
K L Cheesman, and
S D Cheesman, and
R T Chatterton, and
M R Cohen
July 1992,
American journal of obstetrics and gynecology,
K L Cheesman, and
S D Cheesman, and
R T Chatterton, and
M R Cohen
January 1995,
West African journal of medicine,
K L Cheesman, and
S D Cheesman, and
R T Chatterton, and
M R Cohen
January 1989,
Acta Europaea fertilitatis,
K L Cheesman, and
S D Cheesman, and
R T Chatterton, and
M R Cohen
January 1976,
Materia medica Polona. Polish journal of medicine and pharmacy,
K L Cheesman, and
S D Cheesman, and
R T Chatterton, and
M R Cohen
March 1982,
Obstetrics and gynecology,
K L Cheesman, and
S D Cheesman, and
R T Chatterton, and
M R Cohen
March 1994,
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology,
K L Cheesman, and
S D Cheesman, and
R T Chatterton, and
M R Cohen
October 1989,
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae,
K L Cheesman, and
S D Cheesman, and
R T Chatterton, and
M R Cohen
January 1989,
Proceedings of the Chinese Academy of Medical Sciences and the Peking Union Medical College = Chung-kuo i hsueh k'o hsueh yuan, Chung-kuo hsieh ho i k'o ta hsueh hsueh pao,
K L Cheesman, and
S D Cheesman, and
R T Chatterton, and
M R Cohen
April 2001,
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme,
