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The method of electron paramagnetic resonance with spin-labeled maleimide was used to study variation of the structure of Ca-ATPase of the sarcoplasmic reticulum (SR) in rabbit skeletal muscles under long-term hypercholesterolemia (HC). The rate of the maleimide spin label binding with Ca-ATPase of the SR was decreased in HC, which correlated with a lesser access of spin-labeled thiol groups for potassium ferricyanide and sodium ascorbate. HC led to a considerable reduction in the lability and to enhancement of hydrophobia of the spin-labeled fragment of the enzyme. It is concluded that the disordered function of the SR Ca-pump is a consequence of structural changes in the Ca-ATPase molecule in HC.
A A Timofeev, and
L V Stoĭda, and
O A Azizova, and
A G Maksina, and
G V Chernysheva
April 1984,
Biulleten' eksperimental'noi biologii i meditsiny,
A A Timofeev, and
L V Stoĭda, and
O A Azizova, and
A G Maksina, and
G V Chernysheva
January 1978,
Biulleten' eksperimental'noi biologii i meditsiny,
A A Timofeev, and
L V Stoĭda, and
O A Azizova, and
A G Maksina, and
G V Chernysheva
January 1984,
Nauchnye doklady vysshei shkoly. Biologicheskie nauki,
A A Timofeev, and
L V Stoĭda, and
O A Azizova, and
A G Maksina, and
G V Chernysheva
January 1990,
Ukrainskii biokhimicheskii zhurnal (1978),
A A Timofeev, and
L V Stoĭda, and
O A Azizova, and
A G Maksina, and
G V Chernysheva
January 1981,
Molekuliarnaia biologiia,
A A Timofeev, and
L V Stoĭda, and
O A Azizova, and
A G Maksina, and
G V Chernysheva
June 1984,
Biochemistry international,
A A Timofeev, and
L V Stoĭda, and
O A Azizova, and
A G Maksina, and
G V Chernysheva
May 1980,
Biochimica et biophysica acta,
A A Timofeev, and
L V Stoĭda, and
O A Azizova, and
A G Maksina, and
G V Chernysheva
January 2004,
Zhurnal evoliutsionnoi biokhimii i fiziologii,
A A Timofeev, and
L V Stoĭda, and
O A Azizova, and
A G Maksina, and
G V Chernysheva
May 1986,
European journal of biochemistry,
A A Timofeev, and
L V Stoĭda, and
O A Azizova, and
A G Maksina, and
G V Chernysheva
February 2014,
European journal of oral sciences,
