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A study was conducted examining the properties of 10 clinical isolates of spectinomycin resistant gonococci from patients attending clinics at St Mary's and St Thomas's Hospitals, London. All of the isolates produced beta-lactamase and contained plasmids of 2.6, 4.4, and 24.5 megadaltons and required proline for growth. None produced aminoglycoside modifying enzymes. Resistance to spectinomycin was transferred from some of the isolates by transformation but at a much lower frequency than resistance to streptomycin. The isolates from St Mary's Hospital were detected after therapy with spectinomycin, whereas those from St Thomas's Hospital were not. Four recent non-beta-lactamase producing gonococci isolated at St Mary's Hospital and two isolated at St Thomas's Hospital also were not related to use of spectinomycin.
C A Ison, and
K Littleton, and
K P Shannon, and
C S Easmon, and
I Phillips
January 1990,
Clinical therapeutics,
C A Ison, and
K Littleton, and
K P Shannon, and
C S Easmon, and
I Phillips
May 1985,
Ugeskrift for laeger,
C A Ison, and
K Littleton, and
K P Shannon, and
C S Easmon, and
I Phillips
September 1980,
Ugeskrift for laeger,
C A Ison, and
K Littleton, and
K P Shannon, and
C S Easmon, and
I Phillips
March 1972,
British medical journal,
C A Ison, and
K Littleton, and
K P Shannon, and
C S Easmon, and
I Phillips
December 1971,
British medical journal,
C A Ison, and
K Littleton, and
K P Shannon, and
C S Easmon, and
I Phillips
January 1985,
Indian journal of dermatology, venereology and leprology,
C A Ison, and
K Littleton, and
K P Shannon, and
C S Easmon, and
I Phillips
April 1982,
Lancet (London, England),
C A Ison, and
K Littleton, and
K P Shannon, and
C S Easmon, and
I Phillips
July 1980,
Lancet (London, England),
C A Ison, and
K Littleton, and
K P Shannon, and
C S Easmon, and
I Phillips
March 1964,
Singapore medical journal,
C A Ison, and
K Littleton, and
K P Shannon, and
C S Easmon, and
I Phillips
September 1980,
Lancet (London, England),
