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Chick embryo fibroblasts growing in medium free of pyridine ring precursors of NADH and NADPH replicate several times before multiplication ceases. The rate of glucose transport is progressively enhanced, finally reaching levels several times higher than those normally observed in cells severely depleted of NADH. Whereas normal cells respond to additional glucose by further reducing transport, the NADH-depleted cell is refractory to glucose even at five times the normal glucose concentration. Readdition of nicotinamide does little to restore normal transport within 24 h. On the other hand NAD+ or NADP+ provided simultaneously with glucose results in a sharp decline in measurable transport within 2-4 h. The role of the pyridine nucleotides in this reduction of transport function is for the moment unknown.
H Amos, and
K G Mandel, and
R J Gay
August 1982,
The Biochemical journal,
H Amos, and
K G Mandel, and
R J Gay
May 1981,
Journal of cellular physiology,
H Amos, and
K G Mandel, and
R J Gay
January 1967,
Protoplasma,
H Amos, and
K G Mandel, and
R J Gay
July 1980,
Biochimica et biophysica acta,
H Amos, and
K G Mandel, and
R J Gay
May 1971,
Biochimica et biophysica acta,
H Amos, and
K G Mandel, and
R J Gay
August 1976,
The Biochemical journal,
H Amos, and
K G Mandel, and
R J Gay
December 1977,
Journal of cellular physiology,
H Amos, and
K G Mandel, and
R J Gay
November 1979,
Biochemical and biophysical research communications,
H Amos, and
K G Mandel, and
R J Gay
October 1973,
Antibiotiki,
H Amos, and
K G Mandel, and
R J Gay
March 1973,
Proceedings of the National Academy of Sciences of the United States of America,
