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In this study normal skin and a range of skin tumours, both benign and malignant, have been examined using monoclonal antibodies to identify the distribution and morphology of Langerhans' cells and T cells, the distribution of T lymphocytes and their subsets have been analysed using monoclonal anti-T cell antibodies. The results indicated that Langerhans' cells can be reliably identified in both normal and malignant skin biopsies using monoclonal antibodies. A striking finding to emerge was that in benign skin lesions Langerhans' cells were increased, whereas in malignant tumours they were not only markedly depleted or absent but also grossly stunted and deformed in outline. The majority of lymphocytes surrounding these skin tumours were shown to be T cells with helper cells outnumbering suppressor cells by a ratio from 2 to 5:1. This study shows the usefulness of immunohistological techniques using monoclonal antibodies for examining the morphology and distribution of Langerhans' cells in skin pathology. In addition they are particularly appropriate for identifying their topographical relationships with other immunologically important cells such as T cells.
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K C Gatter, and
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July 1983,
European journal of cancer & clinical oncology,
K C Gatter, and
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January 1986,
Virchows Archiv. A, Pathological anatomy and histopathology,
K C Gatter, and
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March 1984,
Histopathology,
K C Gatter, and
H B Morris, and
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December 1992,
Pathology, research and practice,
K C Gatter, and
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D Y Mason
January 1993,
In vivo (Athens, Greece),
K C Gatter, and
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D Y Mason
October 1989,
Archives of histology and cytology,
K C Gatter, and
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B Roach, and
P Mortimer, and
K A Fleming, and
D Y Mason
January 1987,
Medicina cutanea ibero-latino-americana,
K C Gatter, and
H B Morris, and
B Roach, and
P Mortimer, and
K A Fleming, and
D Y Mason
September 1993,
Yan ke xue bao = Eye science,
K C Gatter, and
H B Morris, and
B Roach, and
P Mortimer, and
K A Fleming, and
D Y Mason
May 1987,
Pediatric dermatology,
