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This basic study was performed to determine whether the anti-tumor effect of lymphocytes obtained from the peripheral blood of a tumor bearing host can be increased when cultured in vitro with Mitomycin C (MMC)-treated AH109A tumor cells, using interleukin-2 (IL-2). Donryu rats were used as tumor bearing hosts. The following results were obtained. Weak anti-tumor activity of lymphocytes was noted 7 days after lymphocytes were cultured in the medium to which only IL-2 was added. Anti-tumor activity was augmented by adding antigen (MMC treated tumor cells) to the above (1). Anti-tumor activity was further augmented by adding to (2) above antigen presenting cells such as intraperitoneal exudate macrophages or peripheral hole leukocytes. Anti-tumor activity of lymphocytes was detected when IL-2 and MMC treated antigen were added to the peripheral hole leukocytes containing the lymphocytes.
K Horie, and
T Yamasaki, and
K Nishimura, and
S Tsuchiya, and
A Yoshizawa, and
R Akimoto, and
H Watanabe, and
K Shirasawa, and
M Suzuki, and
Y Tsujimoto
July 1985,
Nihon Geka Gakkai zasshi,
K Horie, and
T Yamasaki, and
K Nishimura, and
S Tsuchiya, and
A Yoshizawa, and
R Akimoto, and
H Watanabe, and
K Shirasawa, and
M Suzuki, and
Y Tsujimoto
January 1979,
Experientia,
K Horie, and
T Yamasaki, and
K Nishimura, and
S Tsuchiya, and
A Yoshizawa, and
R Akimoto, and
H Watanabe, and
K Shirasawa, and
M Suzuki, and
Y Tsujimoto
January 1979,
Neoplasma,
K Horie, and
T Yamasaki, and
K Nishimura, and
S Tsuchiya, and
A Yoshizawa, and
R Akimoto, and
H Watanabe, and
K Shirasawa, and
M Suzuki, and
Y Tsujimoto
January 1979,
Neoplasma,
K Horie, and
T Yamasaki, and
K Nishimura, and
S Tsuchiya, and
A Yoshizawa, and
R Akimoto, and
H Watanabe, and
K Shirasawa, and
M Suzuki, and
Y Tsujimoto
January 1982,
Neoplasma,
K Horie, and
T Yamasaki, and
K Nishimura, and
S Tsuchiya, and
A Yoshizawa, and
R Akimoto, and
H Watanabe, and
K Shirasawa, and
M Suzuki, and
Y Tsujimoto
February 1974,
European journal of cancer,
K Horie, and
T Yamasaki, and
K Nishimura, and
S Tsuchiya, and
A Yoshizawa, and
R Akimoto, and
H Watanabe, and
K Shirasawa, and
M Suzuki, and
Y Tsujimoto
January 1989,
Archives of oto-rhino-laryngology,
K Horie, and
T Yamasaki, and
K Nishimura, and
S Tsuchiya, and
A Yoshizawa, and
R Akimoto, and
H Watanabe, and
K Shirasawa, and
M Suzuki, and
Y Tsujimoto
April 1988,
Journal of immunology (Baltimore, Md. : 1950),
K Horie, and
T Yamasaki, and
K Nishimura, and
S Tsuchiya, and
A Yoshizawa, and
R Akimoto, and
H Watanabe, and
K Shirasawa, and
M Suzuki, and
Y Tsujimoto
June 1963,
Journal of biochemistry,
K Horie, and
T Yamasaki, and
K Nishimura, and
S Tsuchiya, and
A Yoshizawa, and
R Akimoto, and
H Watanabe, and
K Shirasawa, and
M Suzuki, and
Y Tsujimoto
August 1974,
Gan,
