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Extracts of rat atria are potent stimulators of sodium and urine excretion, and relax vascular and intestinal smooth muscle preparations. The structures of six biologically active peptides obtained from atrial extracts are reported here. Ion exchange chromatography of a low molecular weight fraction obtained by gel filtration of atrial extracts produced two natriuretic fractions: the first induced relaxation of intestinal smooth muscle strips only, whereas the second also relaxed vascular strips as well. From the first fraction four pure biologically active peptides obtained by reverse phase HPLC have been sequenced: the 21 amino acid peptide, designated atriopeptin I, and three homologs (des- ser1 -, des- ser1 -ser2-, and des- ser21 - atriopeptin I). From the second fraction two pure biologically active peptides were obtained, which had C-terminal extensions of atriopeptin I: atriopeptins II (23 amino acid residues) and III (24 residues), having respectively phe-arg and phe-arg-tyr C-termini. These results suggest that this family of six peptides, sharing the same 17 membered ring formed by an internal cystine disulfide, is derived from a common high molecular weight precursor.
D M Geller, and
M G Currie, and
K Wakitani, and
B R Cole, and
S P Adams, and
K F Fok, and
N R Siegel, and
S R Eubanks, and
G R Galluppi, and
P Needleman
June 2014,
Protein and peptide letters,
D M Geller, and
M G Currie, and
K Wakitani, and
B R Cole, and
S P Adams, and
K F Fok, and
N R Siegel, and
S R Eubanks, and
G R Galluppi, and
P Needleman
January 1980,
Progress in hemostasis and thrombosis,
D M Geller, and
M G Currie, and
K Wakitani, and
B R Cole, and
S P Adams, and
K F Fok, and
N R Siegel, and
S R Eubanks, and
G R Galluppi, and
P Needleman
January 1971,
Biochemical and biophysical research communications,
D M Geller, and
M G Currie, and
K Wakitani, and
B R Cole, and
S P Adams, and
K F Fok, and
N R Siegel, and
S R Eubanks, and
G R Galluppi, and
P Needleman
March 1959,
Arquivo de patologia,
D M Geller, and
M G Currie, and
K Wakitani, and
B R Cole, and
S P Adams, and
K F Fok, and
N R Siegel, and
S R Eubanks, and
G R Galluppi, and
P Needleman
January 1976,
Duodecim; laaketieteellinen aikakauskirja,
D M Geller, and
M G Currie, and
K Wakitani, and
B R Cole, and
S P Adams, and
K F Fok, and
N R Siegel, and
S R Eubanks, and
G R Galluppi, and
P Needleman
January 1997,
The Journal of cell biology,
D M Geller, and
M G Currie, and
K Wakitani, and
B R Cole, and
S P Adams, and
K F Fok, and
N R Siegel, and
S R Eubanks, and
G R Galluppi, and
P Needleman
January 1983,
Cold Spring Harbor symposia on quantitative biology,
D M Geller, and
M G Currie, and
K Wakitani, and
B R Cole, and
S P Adams, and
K F Fok, and
N R Siegel, and
S R Eubanks, and
G R Galluppi, and
P Needleman
January 1992,
Agents and actions. Supplements,
D M Geller, and
M G Currie, and
K Wakitani, and
B R Cole, and
S P Adams, and
K F Fok, and
N R Siegel, and
S R Eubanks, and
G R Galluppi, and
P Needleman
January 2015,
BioMed research international,
D M Geller, and
M G Currie, and
K Wakitani, and
B R Cole, and
S P Adams, and
K F Fok, and
N R Siegel, and
S R Eubanks, and
G R Galluppi, and
P Needleman
October 2004,
Mini reviews in medicinal chemistry,
