-transparent.png){kind=logo}
The new potent tumor promoters teleocidin and debromoaplysiatoxin , which are structurally unrelated to phorbol esters, activate Ca2+-activated, phospholipid-dependent protein kinase (protein kinase C). The concentrations of 12-O-tetradecanoylphorbol-13-acetate, teleocidin and debromoaplysiatoxin for half-maximum activation of protein kinase C were found to be approximately 3 ng/ml, 40 ng/ml and 400 ng/ml, respectively. These three types of tumor promoters bind to protein kinase C, and appear to exhibit their pleiotropic actions through activation of this enzyme.
Related Publications
H Fujiki, and
Y Tanaka, and
R Miyake, and
U Kikkawa, and
Y Nishizuka, and
T Sugimura
January 1987,
Advances in cancer research,
H Fujiki, and
Y Tanaka, and
R Miyake, and
U Kikkawa, and
Y Nishizuka, and
T Sugimura
July 1982,
The Journal of biological chemistry,
H Fujiki, and
Y Tanaka, and
R Miyake, and
U Kikkawa, and
Y Nishizuka, and
T Sugimura
January 1983,
The Journal of biological chemistry,
H Fujiki, and
Y Tanaka, and
R Miyake, and
U Kikkawa, and
Y Nishizuka, and
T Sugimura
August 1983,
Biochemical and biophysical research communications,
H Fujiki, and
Y Tanaka, and
R Miyake, and
U Kikkawa, and
Y Nishizuka, and
T Sugimura
January 1983,
Methods in enzymology,
H Fujiki, and
Y Tanaka, and
R Miyake, and
U Kikkawa, and
Y Nishizuka, and
T Sugimura
May 1990,
Israel journal of medical sciences,
H Fujiki, and
Y Tanaka, and
R Miyake, and
U Kikkawa, and
Y Nishizuka, and
T Sugimura
January 1991,
Journal of inherited metabolic disease,
H Fujiki, and
Y Tanaka, and
R Miyake, and
U Kikkawa, and
Y Nishizuka, and
T Sugimura
January 1983,
Princess Takamatsu symposia,
H Fujiki, and
Y Tanaka, and
R Miyake, and
U Kikkawa, and
Y Nishizuka, and
T Sugimura
August 1985,
Biochemical and biophysical research communications,
H Fujiki, and
Y Tanaka, and
R Miyake, and
U Kikkawa, and
Y Nishizuka, and
T Sugimura
April 1986,
Carcinogenesis,
