-transparent.png){kind=logo}
The relationship between the dose and anxiolytic effects of diazepam and the serum concentrations of diazepam and nordiazepam were examined in groups of acutely and chronically anxious patients. The results showed a significant correlation between dose and serum nordiazepam concentrations after short-term (14-day) administration, but no significant association between clinical symptoms of anxiety and serum diazepam and nordiazepam. We conclude that the main value of serum benzodiazepine measurements in anxious patients in assessing compliance, particularly in patients suspected of taking more than the recommended dose. Serum nordiazepam is a more consistent index of dosage after chronic therapy than serum diazepam because it has a longer elimination half-time.
P Tyrer, and
I Treasaden, and
K Moreton, and
P Riley, and
R J Flanagan, and
S Dawling
March 1984,
Journal of pharmaceutical sciences,
P Tyrer, and
I Treasaden, and
K Moreton, and
P Riley, and
R J Flanagan, and
S Dawling
December 1980,
Clinical chemistry,
P Tyrer, and
I Treasaden, and
K Moreton, and
P Riley, and
R J Flanagan, and
S Dawling
April 1988,
The Journal of pharmacology and experimental therapeutics,
P Tyrer, and
I Treasaden, and
K Moreton, and
P Riley, and
R J Flanagan, and
S Dawling
January 1991,
Psychopharmacology,
P Tyrer, and
I Treasaden, and
K Moreton, and
P Riley, and
R J Flanagan, and
S Dawling
June 2001,
Veterinary and human toxicology,
P Tyrer, and
I Treasaden, and
K Moreton, and
P Riley, and
R J Flanagan, and
S Dawling
January 1979,
Progress in neuro-psychopharmacology,
P Tyrer, and
I Treasaden, and
K Moreton, and
P Riley, and
R J Flanagan, and
S Dawling
April 1983,
Journal of clinical psychopharmacology,
P Tyrer, and
I Treasaden, and
K Moreton, and
P Riley, and
R J Flanagan, and
S Dawling
November 1995,
Pharmacological research,
P Tyrer, and
I Treasaden, and
K Moreton, and
P Riley, and
R J Flanagan, and
S Dawling
March 1971,
Archives of general psychiatry,
P Tyrer, and
I Treasaden, and
K Moreton, and
P Riley, and
R J Flanagan, and
S Dawling
February 1978,
The Journal of clinical psychiatry,
