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In allergic patients the authors previously observed high proportions of circulating T lymphocytes bearing Ia antigens, assumed to be "activated" T cells. In the present investigation they employed other T cell activation markers (4F2, insulin receptor, MLR4) which differ in the kinetics of appearance upon the surface of stimulated T cells. They report high proportions of Ia and 4F2-positive T cells, normal levels of MLR4-positive T lymphocytes and no insulin binding on T cells. However, T cells of allergic subjects are able to express insulin receptors in PHA-induced culture, such as normal subjects do. The authors conclude that these data, supported by similar observations in autoimmune diseases, indicates differences between in vivo and in vitro features of expression of T cell activation markers. In addition the autologous mixed lymphocyte reaction (AMLR) in atopic patients was studied. The results indicate that AMLR responsiveness is defective in allergic patients.
W Dirienzo, and
M Bagnasco, and
M Caria, and
G Chimini, and
G Ciprandi, and
S Ferrini, and
G W Canonica
February 1983,
Annals of allergy,
W Dirienzo, and
M Bagnasco, and
M Caria, and
G Chimini, and
G Ciprandi, and
S Ferrini, and
G W Canonica
May 1985,
Journal of clinical immunology,
W Dirienzo, and
M Bagnasco, and
M Caria, and
G Chimini, and
G Ciprandi, and
S Ferrini, and
G W Canonica
June 1984,
Journal of clinical & laboratory immunology,
W Dirienzo, and
M Bagnasco, and
M Caria, and
G Chimini, and
G Ciprandi, and
S Ferrini, and
G W Canonica
February 1983,
Allergy,
W Dirienzo, and
M Bagnasco, and
M Caria, and
G Chimini, and
G Ciprandi, and
S Ferrini, and
G W Canonica
April 1989,
Human immunology,
W Dirienzo, and
M Bagnasco, and
M Caria, and
G Chimini, and
G Ciprandi, and
S Ferrini, and
G W Canonica
January 1986,
Diagnostic immunology,
W Dirienzo, and
M Bagnasco, and
M Caria, and
G Chimini, and
G Ciprandi, and
S Ferrini, and
G W Canonica
January 1988,
Hepatology (Baltimore, Md.),
W Dirienzo, and
M Bagnasco, and
M Caria, and
G Chimini, and
G Ciprandi, and
S Ferrini, and
G W Canonica
March 1980,
Journal of immunology (Baltimore, Md. : 1950),
W Dirienzo, and
M Bagnasco, and
M Caria, and
G Chimini, and
G Ciprandi, and
S Ferrini, and
G W Canonica
August 1987,
International journal of cancer,
W Dirienzo, and
M Bagnasco, and
M Caria, and
G Chimini, and
G Ciprandi, and
S Ferrini, and
G W Canonica
March 1984,
Scandinavian journal of immunology,
