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The antitumor activity of schizophyllan (SPG) against syngeneic ACI/N rat tumor, AMC-60 fibrosarcoma and BC-47 bladder cancer was investigated. Intramuscular injection of SPG caused a marked suppression of AMC-60 tumor growth. Results obtained with cytotoxicity tests in vitro and lymphoblastogeneic response in vitro suggest the association of enhanced macrophage cytostasis and high reactivity of lymphoid cells with the resistance of the host to AMC-60 tumor. Moreover, SPG showed pronounced antitumor activity against BC-47 bladder cancer. The highest therapeutic effectiveness was obtained when SPG injection was started at an advanced stage of the tumor, 4 out of 15 rats treated being completely cured of cancer. Cytotoxicity tests in vitro and neutralization tests in vivo indicated the important role of cytotoxic lymphocytes as well as activated macrophages in the host defence mechanism against BC-47 cancer. This, taken together with the fact that the rats cured completely by SPG therapy acquired transplantation resistance to BC-47 cancer, shows that SPG may promote tumor immunity in the host.
M Mitani, and
T Arika, and
T Matsuo, and
T Asano
January 1984,
Cancer immunology, immunotherapy : CII,
M Mitani, and
T Arika, and
T Matsuo, and
T Asano
January 1993,
Cancer research,
M Mitani, and
T Arika, and
T Matsuo, and
T Asano
October 1985,
Gan to kagaku ryoho. Cancer & chemotherapy,
M Mitani, and
T Arika, and
T Matsuo, and
T Asano
February 1978,
Gan,
M Mitani, and
T Arika, and
T Matsuo, and
T Asano
September 1989,
Nihon Geka Gakkai zasshi,
M Mitani, and
T Arika, and
T Matsuo, and
T Asano
July 1985,
Nihon Gan Chiryo Gakkai shi,
M Mitani, and
T Arika, and
T Matsuo, and
T Asano
January 1991,
Cancer immunology, immunotherapy : CII,
M Mitani, and
T Arika, and
T Matsuo, and
T Asano
October 1982,
Cancer research,
M Mitani, and
T Arika, and
T Matsuo, and
T Asano
April 1982,
The Japanese journal of experimental medicine,
M Mitani, and
T Arika, and
T Matsuo, and
T Asano
January 1979,
Cellular and molecular biology, including cyto-enzymology,
