-transparent.png){kind=logo}
Edetic acid labeled with chromium 51 was injected intravenously in normal rats and in rats with streptozocin-induced diabetes. One hour after the injection the animals were killed and the concentrations of edetic acid 51Cr in vitreous body, retina, and brain were determined. No significant difference was observed between the two groups for either tissue. In a second series, a mixture of tritiated 1-glucose and aminohippuric acid tagged with carbon 14 was injected instead of edetic acid. A substantial accumulation of aminohippuric acid 14C compared with tritiated 1-glucose was observed in the vitreous body and the brain of diabetic rats in comparison with the control group. It is concluded that untreated streptozocin-induced diabetes in rats for one to two weeks will not cause a generalized increase in the permeability of the blood-ocular or the blood-brain barriers, but organic acids may accumulate in the vitreous body as well as in the brain as a consequence of reduced outward transport through these barriers.
O Mäepea, and
C Karlsson, and
A Alm
June 1983,
Archives of ophthalmology (Chicago, Ill. : 1960),
O Mäepea, and
C Karlsson, and
A Alm
March 1995,
Neuroscience letters,
O Mäepea, and
C Karlsson, and
A Alm
October 1982,
Investigative ophthalmology & visual science,
O Mäepea, and
C Karlsson, and
A Alm
April 1990,
Diabetes,
O Mäepea, and
C Karlsson, and
A Alm
January 2008,
Current pharmaceutical design,
O Mäepea, and
C Karlsson, and
A Alm
January 1991,
Ophthalmic surgery,
O Mäepea, and
C Karlsson, and
A Alm
January 1987,
Diabetes,
O Mäepea, and
C Karlsson, and
A Alm
December 2006,
American journal of physiology. Heart and circulatory physiology,
O Mäepea, and
C Karlsson, and
A Alm
July 1984,
Archives of ophthalmology (Chicago, Ill. : 1960),
O Mäepea, and
C Karlsson, and
A Alm
January 1989,
Diabetes,
