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Isomeric compounds of N alpha-arylsulfonylated amides of omega-amidinophenyl-alpha-aminoalkylcarboxylic acids--N alpha-amidinophenylsulfonylated amides or N alpha-arylsulfonylated amidino anilides of omega-phenyl-alpha-aminoalkylcarboxylic acids, respectively--possess weak antithrombin activity as compared to the derivatives of the basic structure. Thus, the assumption is corroborated that specific enzyme-inhibitor interactions account for the high antithrombin activity of certain derivatives of omega-amidinophenyl-alpha-aminoalkylcarboxylic acids. In contrast, amidinoanilides of N alpha-substituted omega-phenyl-alpha-aminoalkylcarboxylic acids are potent inhibitors of trypsin and plasmin, their inhibitory activity approaches that of primary amides of N alpha-substituted omega-amidinophenyl-alpha-aminoalkylcarboxylic acids.
J Stürzebecher, and
F Markwardt, and
H Vieweg, and
G Wagner, and
P Walsmann
January 1982,
Folia haematologica (Leipzig, Germany : 1928),
J Stürzebecher, and
F Markwardt, and
H Vieweg, and
G Wagner, and
P Walsmann
October 1980,
Thrombosis research,
J Stürzebecher, and
F Markwardt, and
H Vieweg, and
G Wagner, and
P Walsmann
February 1987,
Die Pharmazie,
J Stürzebecher, and
F Markwardt, and
H Vieweg, and
G Wagner, and
P Walsmann
April 1993,
Thrombosis research,
J Stürzebecher, and
F Markwardt, and
H Vieweg, and
G Wagner, and
P Walsmann
October 1977,
Biochimica et biophysica acta,
J Stürzebecher, and
F Markwardt, and
H Vieweg, and
G Wagner, and
P Walsmann
November 1983,
Die Pharmazie,
J Stürzebecher, and
F Markwardt, and
H Vieweg, and
G Wagner, and
P Walsmann
October 1981,
Biochimica et biophysica acta,
J Stürzebecher, and
F Markwardt, and
H Vieweg, and
G Wagner, and
P Walsmann
June 1969,
Pharmaceutisch weekblad,
J Stürzebecher, and
F Markwardt, and
H Vieweg, and
G Wagner, and
P Walsmann
April 1969,
The Journal of biological chemistry,
J Stürzebecher, and
F Markwardt, and
H Vieweg, and
G Wagner, and
P Walsmann
April 2003,
Biochemistry,
