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Antibodies to chromosome 21 coded cell surface components block binding of human alpha interferon but not gamma interferon to human cells. 1984
L M Shulman, and
M E Kamarck, and
D L Slate, and
F H Ruddle, and
A W Branca, and
C Baglioni, and
B L Maxwell, and
J Gutterman, and
P Anderson, and
C Nagler, and
J Vilcek
Department of Biology, Yale University, New Haven, Connecticut 06520, USA.
Antisera raised against a human X mouse hybrid cell line containing human chromosome 21 as its only human chromosome, block induction of an antiviral state by human alpha interferon (IFN-alpha), block induction of (2'-5')oligoisoadenylate synthetase [2'-5')A synthetase), and block binding of 125I-labeled and 35S-labeled recombinant, human IFN-alpha A, but not 125I-labeled IFN-gamma, to cell surface receptors. The data presented clearly demonstrate that the cell surface receptors for IFN-alpha and IFN-gamma are different, and provide independent evidence of the role of a chromosome 21 coded cell surface molecule in the pathway to the generation of the antiviral state.
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