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This review considers the place of surgery with its two indications: 1) suppression of the target organ of gastrin hypersecretion (total gastrectomy or other surgical procedures on the stomach), 2) radical tumour excision. The authors also discuss the use of anti-secretory drugs currently used in the Zollinger-Ellison syndrome and the respective usefulness of these different techniques in acute and chronic Zollinger-Ellison syndromes. The role of anti-tumour chemotherapy is also discussed.
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