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About 25% of human T cells isolated from cord blood acquired la antigens, following stimulation with phytohemagglutinin (PHA) for 72 hr. This percentage is markedly lower than that found in PHA-activated T-cell populations (PHA-T cells) isolated from peripheral blood of adults. The low expression of la antigens by human T cells from cord blood does not reflect abnormalities in the sensitivity to PHA stimulation and/or in the kinetics of induction of la antigens. PHA-T cells from cord blood display a low stimulatory activity in autologous mixed lymphocyte reactions (MLR). The defect does not reflect a nonspecific abnormality in the stimulatory activity of PHA-T cells from cord blood, since the latter do not differ from PHA-T cells from adults in their ability to stimulate allogeneic T cells from adults. Furthermore the defect does not reflect a nonspecific abnormality in the proliferative response of T cells from cord blood, since the latter display a normal proliferative response to PHA-T cells from adults. The defect in the proliferative response is not restricted to the autologous MLR with PHA-T cells, since it was found also in autologous MLR with non-T cells as stimulators. Correlation of the temporal evolution of the abnormalities of human T cells with the maturation of the immune system may contribute to our understanding of the role of la antigens in cell-cell interactions and of the biological significance of abnormalities of autologous MLR.
M Scudeletti, and
F Torrielli, and
D Pende, and
C Piccardo, and
F Indiveri, and
S Ferrone
January 1982,
European journal of immunology,
M Scudeletti, and
F Torrielli, and
D Pende, and
C Piccardo, and
F Indiveri, and
S Ferrone
May 1983,
Behring Institute Mitteilungen,
M Scudeletti, and
F Torrielli, and
D Pende, and
C Piccardo, and
F Indiveri, and
S Ferrone
July 1985,
Arerugi = [Allergy],
M Scudeletti, and
F Torrielli, and
D Pende, and
C Piccardo, and
F Indiveri, and
S Ferrone
November 1981,
Nihon Ketsueki Gakkai zasshi : journal of Japan Haematological Society,
M Scudeletti, and
F Torrielli, and
D Pende, and
C Piccardo, and
F Indiveri, and
S Ferrone
December 1977,
The Journal of experimental medicine,
M Scudeletti, and
F Torrielli, and
D Pende, and
C Piccardo, and
F Indiveri, and
S Ferrone
October 1986,
Cellular immunology,
M Scudeletti, and
F Torrielli, and
D Pende, and
C Piccardo, and
F Indiveri, and
S Ferrone
January 1986,
Cellular immunology,
M Scudeletti, and
F Torrielli, and
D Pende, and
C Piccardo, and
F Indiveri, and
S Ferrone
December 1980,
Journal of immunology (Baltimore, Md. : 1950),
M Scudeletti, and
F Torrielli, and
D Pende, and
C Piccardo, and
F Indiveri, and
S Ferrone
January 1983,
La Ricerca in clinica e in laboratorio,
M Scudeletti, and
F Torrielli, and
D Pende, and
C Piccardo, and
F Indiveri, and
S Ferrone
September 1982,
Arerugi = [Allergy],
