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The effects of a synthetic alpha-human atrial natriuretic polypeptide (alpha-hANP) on renal hemodynamics and urine formation were investigated in anesthetized dogs. Intrarenal arterial infusion of the peptide (1.0 microgram/min) increased renal blood flow, glomerular filtration rate and urine flow with no change in systemic blood pressure. A lower dose of alpha-hANP (0.2 micrograms/min) produced a significant diuresis and natriuresis, while renal hemodynamics remained unchanged. The urinary excretion of Na, Cl and Ca was increased in proportion to the urine flow. We propose that alpha-hANP inhibits tubular reabsorption of electrolytes, and in higher dose produces renal vasodilation.
T Yukimura, and
K Ito, and
T Takenaga, and
K Yamamoto, and
K Kangawa, and
H Matsuo
January 1987,
Nihon yakurigaku zasshi. Folia pharmacologica Japonica,
T Yukimura, and
K Ito, and
T Takenaga, and
K Yamamoto, and
K Kangawa, and
H Matsuo
January 1993,
Clinical and experimental hypertension (New York, N.Y. : 1993),
T Yukimura, and
K Ito, and
T Takenaga, and
K Yamamoto, and
K Kangawa, and
H Matsuo
March 1985,
European journal of pharmacology,
T Yukimura, and
K Ito, and
T Takenaga, and
K Yamamoto, and
K Kangawa, and
H Matsuo
January 1986,
European journal of pharmacology,
T Yukimura, and
K Ito, and
T Takenaga, and
K Yamamoto, and
K Kangawa, and
H Matsuo
August 1986,
Acta physiologica Scandinavica,
T Yukimura, and
K Ito, and
T Takenaga, and
K Yamamoto, and
K Kangawa, and
H Matsuo
March 1985,
Life sciences,
T Yukimura, and
K Ito, and
T Takenaga, and
K Yamamoto, and
K Kangawa, and
H Matsuo
June 1987,
Sheng li xue bao : [Acta physiologica Sinica],
T Yukimura, and
K Ito, and
T Takenaga, and
K Yamamoto, and
K Kangawa, and
H Matsuo
May 1985,
The New England journal of medicine,
T Yukimura, and
K Ito, and
T Takenaga, and
K Yamamoto, and
K Kangawa, and
H Matsuo
January 1985,
Clinical and experimental hypertension. Part A, Theory and practice,
T Yukimura, and
K Ito, and
T Takenaga, and
K Yamamoto, and
K Kangawa, and
H Matsuo
April 1988,
Scientia Sinica. Series B, Chemical, biological, agricultural, medical & earth sciences,
