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In the present study we tested the fit of the Single Major Locus (SML) hypothesis, using segregation analysis for single families of affective probands treated with lithium salts, with second degree relatives included. We tested the segregation pattern for every family with two different sets of parameters: one dominant for a group that did not relapse on lithium treatment and one recessive for a group that did. We calculated the likelihood ratios for each family. The results of this study partially confirm the importance of outcome on lithium treatment in susceptibility to affective disorders. However, application of segregation analysis suggested that there is genetic heterogeneity that cannot be completely detected when using only the simple pharmacological criterion of outcome on lithium.
E Smeraldi, and
A Petroccione, and
M Gasperini, and
F Macciardi, and
A Orsini
February 1990,
Archives of psychiatric nursing,
E Smeraldi, and
A Petroccione, and
M Gasperini, and
F Macciardi, and
A Orsini
March 1985,
Acta psiquiatrica y psicologica de America latina,
E Smeraldi, and
A Petroccione, and
M Gasperini, and
F Macciardi, and
A Orsini
January 1984,
Journal of psychiatric research,
E Smeraldi, and
A Petroccione, and
M Gasperini, and
F Macciardi, and
A Orsini
February 1965,
Jornal do medico,
E Smeraldi, and
A Petroccione, and
M Gasperini, and
F Macciardi, and
A Orsini
November 1981,
Acta psychiatrica Scandinavica,
E Smeraldi, and
A Petroccione, and
M Gasperini, and
F Macciardi, and
A Orsini
January 1992,
Pharmacopsychiatry,
E Smeraldi, and
A Petroccione, and
M Gasperini, and
F Macciardi, and
A Orsini
December 1994,
American journal of medical genetics,
E Smeraldi, and
A Petroccione, and
M Gasperini, and
F Macciardi, and
A Orsini
November 1977,
Acta psychiatrica Scandinavica,
E Smeraldi, and
A Petroccione, and
M Gasperini, and
F Macciardi, and
A Orsini
November 1977,
Hippokrates,
E Smeraldi, and
A Petroccione, and
M Gasperini, and
F Macciardi, and
A Orsini
April 1985,
Biological psychiatry,
