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The authors review their recent research involving the generation of cytotoxic T lymphocytes (CTL) directed against HLA-DR antigens. A mouse anti-human xenogeneic system first suggested that HLA-DR antigens could be recognized by CTL. Human allogeneic CTL specific for HLA-DR6 were generated and found to be OKT4+. The fact that these CTL were OKT4+ while anti HLA-A,B CTL were OKT8+ suggested that these T cell surface antigens may be involved in MHC antigen recognition; ie, they may be part of the T cell receptor. These OKT4+, HLA-DR specific CTL were further used to generate monoclonal antibodies (1) which block cytolysis and define novel antigens involved in the CTL-target interaction and (2) which define an antigenic complex on alloantigen activated T cells.
S J Burakoff, and
C Clayberger, and
M Hemler, and
A M Krensky, and
C S Reiss, and
E Robbins, and
F Sanchez-Madrid, and
T A Springer, and
J L Strominger, and
C F Ware
February 1994,
Transplantation,
S J Burakoff, and
C Clayberger, and
M Hemler, and
A M Krensky, and
C S Reiss, and
E Robbins, and
F Sanchez-Madrid, and
T A Springer, and
J L Strominger, and
C F Ware
July 1984,
Journal of immunology (Baltimore, Md. : 1950),
S J Burakoff, and
C Clayberger, and
M Hemler, and
A M Krensky, and
C S Reiss, and
E Robbins, and
F Sanchez-Madrid, and
T A Springer, and
J L Strominger, and
C F Ware
April 1993,
Journal of immunology (Baltimore, Md. : 1950),
S J Burakoff, and
C Clayberger, and
M Hemler, and
A M Krensky, and
C S Reiss, and
E Robbins, and
F Sanchez-Madrid, and
T A Springer, and
J L Strominger, and
C F Ware
January 1984,
Methods in enzymology,
S J Burakoff, and
C Clayberger, and
M Hemler, and
A M Krensky, and
C S Reiss, and
E Robbins, and
F Sanchez-Madrid, and
T A Springer, and
J L Strominger, and
C F Ware
January 1980,
Nature,
S J Burakoff, and
C Clayberger, and
M Hemler, and
A M Krensky, and
C S Reiss, and
E Robbins, and
F Sanchez-Madrid, and
T A Springer, and
J L Strominger, and
C F Ware
June 1983,
Proceedings of the National Academy of Sciences of the United States of America,
S J Burakoff, and
C Clayberger, and
M Hemler, and
A M Krensky, and
C S Reiss, and
E Robbins, and
F Sanchez-Madrid, and
T A Springer, and
J L Strominger, and
C F Ware
December 1975,
The Journal of experimental medicine,
S J Burakoff, and
C Clayberger, and
M Hemler, and
A M Krensky, and
C S Reiss, and
E Robbins, and
F Sanchez-Madrid, and
T A Springer, and
J L Strominger, and
C F Ware
November 1985,
Scandinavian journal of immunology,
S J Burakoff, and
C Clayberger, and
M Hemler, and
A M Krensky, and
C S Reiss, and
E Robbins, and
F Sanchez-Madrid, and
T A Springer, and
J L Strominger, and
C F Ware
January 1981,
Immunogenetics,
S J Burakoff, and
C Clayberger, and
M Hemler, and
A M Krensky, and
C S Reiss, and
E Robbins, and
F Sanchez-Madrid, and
T A Springer, and
J L Strominger, and
C F Ware
April 1997,
Transplantation,
