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The interconversion of zearalenone and zearalenol by rat erythrocytes in vitro has been investigated. The major metabolite obtained by incubating zearalenone with erythrocytes or whole blood from Sprague-Dawley rats was alpha-zearalenol. beta-Zearalenol was also formed but at levels several times lower than those of alpha-zearalenol. In the cell-free haemolysate NADPH was much more effective than NADH as a co-factor in the reduction of zearalenone. The maximal transformation of zearalenone to zearalenol by haemolysates occurred at pH 8.0. Both NAD+ and NADP+ were effective as co-factors in the oxidation of alpha-zearalenol to zearalenone. However, only NADP+ was effective as a co-factor in the oxidation of beta-zearalenol. Conversion of alpha-zearalenol and beta-zearalenol to the corresponding epimer was observed in both erythrocyte suspensions and in cell-free haemolysates. The significance of these findings to the metabolism of zearalenone in vivo is discussed.
W M Chang, and
J K Lin
January 1980,
Acta veterinaria Academiae Scientiarum Hungaricae,
W M Chang, and
J K Lin
October 2008,
Toxicology,
W M Chang, and
J K Lin
June 1984,
Applied and environmental microbiology,
W M Chang, and
J K Lin
February 1981,
Acta pharmacologica et toxicologica,
W M Chang, and
J K Lin
January 1980,
Acta veterinaria Academiae Scientiarum Hungaricae,
W M Chang, and
J K Lin
January 2013,
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment,
W M Chang, and
J K Lin
March 2010,
The Journal of veterinary medical science,
W M Chang, and
J K Lin
March 2019,
Journal of agricultural and food chemistry,
W M Chang, and
J K Lin
December 2007,
Mycotoxin research,
W M Chang, and
J K Lin
August 1988,
Applied and environmental microbiology,
