Thymoma and hypogammaglobulinaemia with and without T suppressor cells. 1984

M K Brenner, and J G Reittie, and H R Chadda, and A Pollock, and G L Asherson

Patients with acquired hypogammaglobulinaemia usually have near normal numbers of B cells and normal T cell function. When hypogammaglobulinaemia occurs in association with thymoma, then B cell numbers have been reported as low, and distinctive T cells are present which inhibit immunoglobulin production by normal cells. It has been suggested that these T cells are responsible for the observed hypogammaglobulinaemia. We report a patient with thymoma and hypogammaglobulinaemia who lacks these distinctive suppressor cells and has normal B cell numbers. It is therefore incorrect to propose a single pathogenic mechanism for hypogammaglobulinaemia in association with thymoma.

UI MeSH Term Description Entries
D007136 Immunoglobulins Multi-subunit proteins which function in IMMUNITY. They are produced by B LYMPHOCYTES from the IMMUNOGLOBULIN GENES. They are comprised of two heavy (IMMUNOGLOBULIN HEAVY CHAINS) and two light chains (IMMUNOGLOBULIN LIGHT CHAINS) with additional ancillary polypeptide chains depending on their isoforms. The variety of isoforms include monomeric or polymeric forms, and transmembrane forms (B-CELL ANTIGEN RECEPTORS) or secreted forms (ANTIBODIES). They are divided by the amino acid sequence of their heavy chains into five classes (IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M) and various subclasses. Globulins, Immune,Immune Globulin,Immune Globulins,Immunoglobulin,Globulin, Immune
D007958 Leukocyte Count The number of WHITE BLOOD CELLS per unit volume in venous BLOOD. A differential leukocyte count measures the relative numbers of the different types of white cells. Blood Cell Count, White,Differential Leukocyte Count,Leukocyte Count, Differential,Leukocyte Number,White Blood Cell Count,Count, Differential Leukocyte,Count, Leukocyte,Counts, Differential Leukocyte,Counts, Leukocyte,Differential Leukocyte Counts,Leukocyte Counts,Leukocyte Counts, Differential,Leukocyte Numbers,Number, Leukocyte,Numbers, Leukocyte
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D010641 Phenotype The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment. Phenotypes
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000361 Agammaglobulinemia An immunologic deficiency state characterized by an extremely low level of generally all classes of gamma-globulin in the blood. Hypogammaglobulinemia,Agammaglobulinemias,Hypogammaglobulinemias
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D001402 B-Lymphocytes Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation. B-Cells, Lymphocyte,B-Lymphocyte,Bursa-Dependent Lymphocytes,B Cells, Lymphocyte,B Lymphocyte,B Lymphocytes,B-Cell, Lymphocyte,Bursa Dependent Lymphocytes,Bursa-Dependent Lymphocyte,Lymphocyte B-Cell,Lymphocyte B-Cells,Lymphocyte, Bursa-Dependent,Lymphocytes, Bursa-Dependent

Related Publications

M K Brenner, and J G Reittie, and H R Chadda, and A Pollock, and G L Asherson
January 1986, The Netherlands journal of medicine,
M K Brenner, and J G Reittie, and H R Chadda, and A Pollock, and G L Asherson
December 1971, Proceedings of the Royal Society of Medicine,
M K Brenner, and J G Reittie, and H R Chadda, and A Pollock, and G L Asherson
August 1977, Irish journal of medical science,
M K Brenner, and J G Reittie, and H R Chadda, and A Pollock, and G L Asherson
January 1979, Journal of clinical pathology. Supplement (Royal College of Pathologists),
M K Brenner, and J G Reittie, and H R Chadda, and A Pollock, and G L Asherson
November 2020, The Indian journal of medical research,
M K Brenner, and J G Reittie, and H R Chadda, and A Pollock, and G L Asherson
January 1976, Proceedings of the Royal Society of Medicine,
M K Brenner, and J G Reittie, and H R Chadda, and A Pollock, and G L Asherson
March 1977, British medical journal,
M K Brenner, and J G Reittie, and H R Chadda, and A Pollock, and G L Asherson
September 1974, Lancet (London, England),
M K Brenner, and J G Reittie, and H R Chadda, and A Pollock, and G L Asherson
June 1994, Presse medicale (Paris, France : 1983),
M K Brenner, and J G Reittie, and H R Chadda, and A Pollock, and G L Asherson
May 1964, British medical journal,
Copied contents to your clipboard!