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The autologous mixed lymphocyte response (AMLR) and the allogeneic mixed lymphocyte response were deficient in a subset of patients with newly diagnosed insulin-dependent diabetes mellitus (IDDM). Using a single set of HLA-identical twins, the cellular and molecular basis of deficient AMLR was investigated and appears to be due to a defect in both responder T cells and stimulator non-T cells. Interleukin-2 production was diminished in the patient but not in the healthy twin. The in vitro addition of purified interleukin-2 enhanced the depressed AMLR in the diseased twin. This suggests that the deficient AMLR in IDDM may be in part due to a deficiency in the production of interleukin-2.
K G Chandy, and
A M Charles, and
A Kershnar, and
B Buckingham, and
N Waldeck, and
S Gupta
June 1983,
Journal of clinical & laboratory immunology,
K G Chandy, and
A M Charles, and
A Kershnar, and
B Buckingham, and
N Waldeck, and
S Gupta
September 1987,
Clinical immunology and immunopathology,
K G Chandy, and
A M Charles, and
A Kershnar, and
B Buckingham, and
N Waldeck, and
S Gupta
March 1984,
Scandinavian journal of immunology,
K G Chandy, and
A M Charles, and
A Kershnar, and
B Buckingham, and
N Waldeck, and
S Gupta
May 1985,
Journal of clinical immunology,
K G Chandy, and
A M Charles, and
A Kershnar, and
B Buckingham, and
N Waldeck, and
S Gupta
January 1983,
Journal of clinical immunology,
K G Chandy, and
A M Charles, and
A Kershnar, and
B Buckingham, and
N Waldeck, and
S Gupta
June 1984,
Journal of clinical & laboratory immunology,
K G Chandy, and
A M Charles, and
A Kershnar, and
B Buckingham, and
N Waldeck, and
S Gupta
August 1982,
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K G Chandy, and
A M Charles, and
A Kershnar, and
B Buckingham, and
N Waldeck, and
S Gupta
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K G Chandy, and
A M Charles, and
A Kershnar, and
B Buckingham, and
N Waldeck, and
S Gupta
January 1983,
Journal of clinical immunology,
K G Chandy, and
A M Charles, and
A Kershnar, and
B Buckingham, and
N Waldeck, and
S Gupta
October 1996,
Journal of investigative medicine : the official publication of the American Federation for Clinical Research,
