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Haemoglobin synthesis was studied in fetal blood samples obtained at 17 to 20 weeks' gestation in 22 women at risk of carrying a fetus with homozygous beta-thalassaemia. A presumptive diagnosis of homozygous beta-thalassaemia was made in four cases, and the pregnancy was terminated. An inconclusive answer was obtained in one case, and the patient also chose to have her pregnancy terminated. Two fetuses were lost as a result of the procedure. Of the remaining 15 pregnancies, 13 proceeded to term and two to 36 weeks; in each case a normal infant or one heterozygous for beta-thalassaemia was delivered. Current efforts should be directed towards improving the blood sampling technology so that fetal blood sampling can be used widely in those countries where thalassaemia is a major problem.
D V Fairweather, and
B Modell, and
V Berdoukas, and
B P Alter, and
D G Nathan, and
D Loukopoulos, and
W Wood, and
J B Clegg, and
D J Weatherall
February 1987,
The Medical journal of Australia,
D V Fairweather, and
B Modell, and
V Berdoukas, and
B P Alter, and
D G Nathan, and
D Loukopoulos, and
W Wood, and
J B Clegg, and
D J Weatherall
October 1978,
The Medical journal of Australia,
D V Fairweather, and
B Modell, and
V Berdoukas, and
B P Alter, and
D G Nathan, and
D Loukopoulos, and
W Wood, and
J B Clegg, and
D J Weatherall
March 1984,
The Medical journal of Australia,
D V Fairweather, and
B Modell, and
V Berdoukas, and
B P Alter, and
D G Nathan, and
D Loukopoulos, and
W Wood, and
J B Clegg, and
D J Weatherall
June 1999,
The Medical journal of Australia,
D V Fairweather, and
B Modell, and
V Berdoukas, and
B P Alter, and
D G Nathan, and
D Loukopoulos, and
W Wood, and
J B Clegg, and
D J Weatherall
November 1979,
Lancet (London, England),
D V Fairweather, and
B Modell, and
V Berdoukas, and
B P Alter, and
D G Nathan, and
D Loukopoulos, and
W Wood, and
J B Clegg, and
D J Weatherall
August 1998,
The Medical journal of Australia,
D V Fairweather, and
B Modell, and
V Berdoukas, and
B P Alter, and
D G Nathan, and
D Loukopoulos, and
W Wood, and
J B Clegg, and
D J Weatherall
May 1987,
The Medical journal of Australia,
D V Fairweather, and
B Modell, and
V Berdoukas, and
B P Alter, and
D G Nathan, and
D Loukopoulos, and
W Wood, and
J B Clegg, and
D J Weatherall
December 1981,
Journal of medical genetics,
D V Fairweather, and
B Modell, and
V Berdoukas, and
B P Alter, and
D G Nathan, and
D Loukopoulos, and
W Wood, and
J B Clegg, and
D J Weatherall
June 1996,
Lancet (London, England),
D V Fairweather, and
B Modell, and
V Berdoukas, and
B P Alter, and
D G Nathan, and
D Loukopoulos, and
W Wood, and
J B Clegg, and
D J Weatherall
November 1981,
The Australian & New Zealand journal of obstetrics & gynaecology,
