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The metabolism of estrone sulfate and dehydroisoandrosterone sulfate to the free, unconjugated steroids, estrone and dehydroisoandrosterone, was demonstrated in more than thirty different tissues from male and female BALB/c mice. The activity of steroid sulfatase, when expressed per mg tissue, was greatest in both the pituitary gland and the adrenal glands. The pituitary gland, however, had the lowest capacity for hydrolysis of steroid sulfates while the liver had the greatest capacity. 17 beta-Hydroxysteroid oxidoreductase activity also was demonstrated in all mouse tissues by the formation of estradiol-17 beta when using estrone sulfate as the substrate. The highest apparent activity for 17 beta-hydroxysteroid oxidoreductase was found in lung tissue, and the greatest capacity to form estradiol-17 beta from estrone sulfate was found in liver, lungs, kidneys and testes. This study demonstrates that the majority of mouse tissues have steroid sulfatase and 17 beta-hydroxysteroid oxidoreductase activities.
L Milewich, and
R L Garcia, and
L W Gerrity
October 1987,
The Journal of clinical endocrinology and metabolism,
L Milewich, and
R L Garcia, and
L W Gerrity
August 1979,
Steroids,
L Milewich, and
R L Garcia, and
L W Gerrity
December 1989,
The Journal of endocrinology,
L Milewich, and
R L Garcia, and
L W Gerrity
April 1981,
Endocrinology,
L Milewich, and
R L Garcia, and
L W Gerrity
January 1990,
Placenta,
L Milewich, and
R L Garcia, and
L W Gerrity
April 1983,
The Journal of clinical endocrinology and metabolism,
L Milewich, and
R L Garcia, and
L W Gerrity
January 1997,
Zentralblatt fur Gynakologie,
L Milewich, and
R L Garcia, and
L W Gerrity
December 1994,
The Prostate,
L Milewich, and
R L Garcia, and
L W Gerrity
December 1965,
Steroids,
L Milewich, and
R L Garcia, and
L W Gerrity
May 1993,
The Journal of steroid biochemistry and molecular biology,
