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Two types of virus particles, intracisternal type A and extracellular type C with budding, were detected in the same cells of BF osteosarcoma, its cultured cell lines, and their BFO tumors in CBA mice. The type C particles were approximately 100 microns in diameter. The buoyant density of the virions was 1.16g/ml in sucrose and 1.07 g/ml in Ficoll. A 72S RNA was demonstrated by gel electrophoresis, but no DNA was detected. Reverse transcriptase activity was also demonstrated in detergent-treated virions. Thus, the particles seem to be RNA virus. Cellular transformation and focus formation were observed after rat and mouse embryo cell monolayers were infected with the virus. The same kind of osteosarcoma was produced by inoculation of cloned transformed cells (BFOSV) of CBA embryo cells into CBA mice. Thus, the virus seems to be an oncornavirus.
Y Nakata, and
T Ochi, and
E Kurisaki, and
H Okano, and
H Hamada, and
K Amitani, and
S Tanabe, and
K Ono, and
Y Sakamoto
July 1978,
Experientia,
Y Nakata, and
T Ochi, and
E Kurisaki, and
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H Hamada, and
K Amitani, and
S Tanabe, and
K Ono, and
Y Sakamoto
April 1974,
Journal of the National Cancer Institute,
Y Nakata, and
T Ochi, and
E Kurisaki, and
H Okano, and
H Hamada, and
K Amitani, and
S Tanabe, and
K Ono, and
Y Sakamoto
January 1976,
Archivos de investigacion medica,
Y Nakata, and
T Ochi, and
E Kurisaki, and
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K Amitani, and
S Tanabe, and
K Ono, and
Y Sakamoto
January 1970,
Bibliotheca haematologica,
Y Nakata, and
T Ochi, and
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H Okano, and
H Hamada, and
K Amitani, and
S Tanabe, and
K Ono, and
Y Sakamoto
January 1978,
Journal of virology,
Y Nakata, and
T Ochi, and
E Kurisaki, and
H Okano, and
H Hamada, and
K Amitani, and
S Tanabe, and
K Ono, and
Y Sakamoto
April 1976,
Virology,
Y Nakata, and
T Ochi, and
E Kurisaki, and
H Okano, and
H Hamada, and
K Amitani, and
S Tanabe, and
K Ono, and
Y Sakamoto
June 1976,
Biochemical and biophysical research communications,
Y Nakata, and
T Ochi, and
E Kurisaki, and
H Okano, and
H Hamada, and
K Amitani, and
S Tanabe, and
K Ono, and
Y Sakamoto
October 1975,
Bibliotheca haematologica,
Y Nakata, and
T Ochi, and
E Kurisaki, and
H Okano, and
H Hamada, and
K Amitani, and
S Tanabe, and
K Ono, and
Y Sakamoto
January 1976,
Medicina,
Y Nakata, and
T Ochi, and
E Kurisaki, and
H Okano, and
H Hamada, and
K Amitani, and
S Tanabe, and
K Ono, and
Y Sakamoto
December 1974,
Journal of the National Cancer Institute,
