Biomaterial Database

Characterization of immunoglobulin A antibody in serum of swine inoculated with transmissible gastroenteritis virus. 1980

Y Kodama, and M Ogata, and Y Simizu

Sera and contents of the small intestine from swine inoculated with transmissible gastroenteritis (TGE) virus were examined for immunoglobulin (Ig) A antibody responses by the radioimmunoprecipitation test with antiporcine IgA serum. When swine were orally inoculated with virulent virus, IgA antibody activity was detected in the contents of the small intestine and in serum from postinoculation days 7 to 56. However, IgA antibody activity was not detected in the contents of the small intestine or serum in swine inoculated IM with attenuated virus. The Ig class of serum of swine inoculated with TGE virus was examined by gel filtration chromatography. When swine were orally inoculated with virulent virus, neutralizing antibody was always detected from both fractions of IgA and IgG Neutralizing antibody ws detected only from the IgG fraction in the serum of swine inoculated IM with attenuated virus. The molecular size of serum IgA antibody was determined by sucrose density gradient centrifugation. The titer of this antibody was the highest at a position between 10.9S- and 7S-marker protein. The antibody consisted almost exclusively of dimers. It appeared that serum IgA antibody always originated from the lymphoid tissue of the intestinal tract. This antibody was regarded as an indicator of active immunity of TGE virus.

UI	MeSH Term	Description	Entries
D007070	Immunoglobulin A	Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions.	IgA,IgA Antibody,IgA1,IgA2,Antibody, IgA
D007109	Immunity	Nonsusceptibility to the invasive or pathogenic effects of foreign microorganisms or to the toxic effect of antigenic substances.	Immune Process,Immune Response,Immune Processes,Immune Responses,Process, Immune,Response, Immune
D007421	Intestine, Small	The portion of the GASTROINTESTINAL TRACT between the PYLORUS of the STOMACH and the ILEOCECAL VALVE of the LARGE INTESTINE. It is divisible into three portions: the DUODENUM, the JEJUNUM, and the ILEUM.	Small Intestine,Intestines, Small,Small Intestines
D005760	Transmissible gastroenteritis virus	A species of CORONAVIRUS causing a fatal disease to pigs under 3 weeks old.	Gastroenteritis Virus of Swine,Gastroenteritis Virus, Porcine Transmissible,Porcine Transmissible Gastroenteritis Virus,TGE Virus,Transmissible Gastroenteritis Virus, Swine,Swine Gastroenteritis Virus,Swine Gastroenteritis Viruses,TGE Viruses
D005761	Gastroenteritis, Transmissible, of Swine	A condition of chronic gastroenteritis in adult pigs and fatal gastroenteritis in piglets caused by a CORONAVIRUS.	Gastroenteritis, Transmissible, Porcine,Porcine Gastroenteritis, Transmissible,Swine Transmissible Gastroenteritis,Transmissible Gastroenteritis of Swine,Porcine Transmissible Gastroenteritis,Gastroenteritides, Porcine Transmissible,Gastroenteritides, Swine Transmissible,Gastroenteritides, Transmissible Porcine,Gastroenteritis, Porcine Transmissible,Gastroenteritis, Swine Transmissible,Gastroenteritis, Transmissible Porcine,Porcine Gastroenteritides, Transmissible,Porcine Transmissible Gastroenteritides,Swine Transmissible Gastroenteritides,Transmissible Gastroenteritides, Porcine,Transmissible Gastroenteritides, Swine,Transmissible Gastroenteritis, Porcine,Transmissible Gastroenteritis, Swine,Transmissible Porcine Gastroenteritides,Transmissible Porcine Gastroenteritis
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D000917	Antibody Formation	The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.	Antibody Production,Antibody Response,Antibody Responses,Formation, Antibody,Production, Antibody,Response, Antibody,Responses, Antibody
D013552	Swine	Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).	Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog