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Urinary metabolites of [6,7-3H]-estriol-3-glucosiduronate and of [6, 7-3H]-estriol in intact female rabbits were analyzed. The separation of urinary metabolites was performed by countercurrent distribution followed by DEAE-Sephadex A-25 column chromatography. Each conjugate was then hydrolyzed with the enzymes and the aglycone thus liberated was identified. In either case, major urinary metabolites were found to be diconjugates, a considerable part of which was glucosiduronate-N-acetylglucosaminide of 17-epiestriol. In addition, estriol-16-glucosiduronate or monoglucosiduronate of 17-epiestriol was identified as a minor urinary metabolite of [6,7-3H]-estriol. From these results, it was concluded that the greater part of the estriol-3-glucosiduronate was converted to diconjugates and that estriol-3-glucosiduronate was probably an intermediate metabolite in the conversion pathway from estriol to diconjugates in this species.
T Miyazaki, and
H Mizukoshi, and
Y Araki, and
N Shimizu
June 1968,
The Journal of clinical endocrinology and metabolism,
T Miyazaki, and
H Mizukoshi, and
Y Araki, and
N Shimizu
November 1965,
Steroids,
T Miyazaki, and
H Mizukoshi, and
Y Araki, and
N Shimizu
May 1970,
Steroids,
T Miyazaki, and
H Mizukoshi, and
Y Araki, and
N Shimizu
December 1965,
Steroids,
T Miyazaki, and
H Mizukoshi, and
Y Araki, and
N Shimizu
May 1966,
Acta endocrinologica,
T Miyazaki, and
H Mizukoshi, and
Y Araki, and
N Shimizu
October 1960,
Endocrinology,
T Miyazaki, and
H Mizukoshi, and
Y Araki, and
N Shimizu
June 1971,
The Journal of clinical endocrinology and metabolism,
T Miyazaki, and
H Mizukoshi, and
Y Araki, and
N Shimizu
February 1969,
The Journal of clinical investigation,
T Miyazaki, and
H Mizukoshi, and
Y Araki, and
N Shimizu
October 1979,
Steroids,
T Miyazaki, and
H Mizukoshi, and
Y Araki, and
N Shimizu
July 1971,
The Journal of clinical endocrinology and metabolism,
