Biomaterial Database

Divergent selection in Japanese quail for the plasma cholesterol response to ACTH. 1980

H L Marks, and H S Siegel

Two lines of Japanese quail were divergently selected for high and low plasma cholesterol levels after three daily injections with 2 IU of adrenocorticotropen (ACTH)/100 g of body weight. Plasma cholesterols were obtained at 31 days of age, just before the first injection, and at 34 days of age, after the last injection. After eight generations of selection, the plasma cholesterol level after ACTH injections in the high line was 34% greater than the level in the control line, whereas the low line level was approximately 14% less than that in the control. Selection differentials were significantly greater in the high line than in the low line. The realized heritability for plasma cholesterol before ACTH treatment calculated by regression of progeny on mid-parent was .25 in the high line and .16 in the low line.

UI	MeSH Term	Description	Entries
D002784	Cholesterol	The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.	Epicholesterol
D003370	Coturnix	A genus of BIRDS in the family Phasianidae, order GALLIFORMES, containing the common European and other Old World QUAIL.	Japanese Quail,Coturnix japonica,Japanese Quails,Quail, Japanese,Quails, Japanese
D000324	Adrenocorticotropic Hormone	An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).	ACTH,Adrenocorticotropin,Corticotropin,1-39 ACTH,ACTH (1-39),Adrenocorticotrophic Hormone,Corticotrophin,Corticotrophin (1-39),Corticotropin (1-39),Hormone, Adrenocorticotrophic,Hormone, Adrenocorticotropic
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D012641	Selection, Genetic	Differential and non-random reproduction of different genotypes, operating to alter the gene frequencies within a population.	Natural Selection,Genetic Selection,Selection, Natural