Biomaterial Database

Melanocytic bronchial carcinoid tumor. 1980

M S Cebelin

A melanin- and serotonin-producing bronchial carcinoid tumor is described. Melanin synthesis by neoplastic cells also containing electron-dense core (neurosecretory granules was documented by electron microscopy and serotonin content was found by biochemical assay to be 201.2 micrograms/g wet weight of tissue. Simultaneous demonstration of "endocrine" properties with characteristics of a cell of neural-crest origin provides strongly confirmatory evidence for the APUD cell theory of Pearse and makes an interesting commentary in regard to general theories of neoplasia.

UI	MeSH Term	Description	Entries
D008543	Melanins	Insoluble polymers of TYROSINE derivatives found in and causing darkness in skin (SKIN PIGMENTATION), hair, and feathers providing protection against SUNBURN induced by SUNLIGHT. CAROTENES contribute yellow and red coloration.	Allomelanins,Melanin,Phaeomelanins
D001984	Bronchial Neoplasms	Tumors or cancer of the BRONCHI.	Neoplasms, Bronchial,Bronchial Neoplasm,Neoplasm, Bronchial
D002276	Carcinoid Tumor	A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)	Argentaffinoma,Carcinoid,Carcinoid, Goblet Cell,Argentaffinomas,Carcinoid Tumors,Carcinoids,Carcinoids, Goblet Cell,Goblet Cell Carcinoid,Goblet Cell Carcinoids,Tumor, Carcinoid,Tumors, Carcinoid
D003528	Carcinoma, Adenoid Cystic	Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)	Cylindroma,Adenocystic Carcinoma,Adenocystic Carcinomas,Adenoid Cystic Carcinoma,Adenoid Cystic Carcinomas,Carcinoma, Adenocystic,Carcinomas, Adenocystic,Carcinomas, Adenoid Cystic,Cylindromas,Cystic Carcinoma, Adenoid,Cystic Carcinomas, Adenoid
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000368	Aged	A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available.	Elderly
D012701	Serotonin	A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.	5-HT,5-Hydroxytryptamine,3-(2-Aminoethyl)-1H-indol-5-ol,Enteramine,Hippophaine,Hydroxytryptamine,5 Hydroxytryptamine