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A substance producing cytotoxicity in tissue culture was detected in stool specimens from all of four patients with pseudomembranous colitis due to antibiotics and in one of 54 with antibiotic-associated diarrhea. These stools also caused enterocolitis when injected intracecally into hamsters. On each occasion, cytotoxicity in tissue culture and enterocolitis in hamsters were neutralized by pretreatment with gas-gangrene antitoxin. The toxicity in both tissue cultures and hamsters could be reproduced with broth cultures of clostridia strains isolated from four of the five stools. These results suggest that toxin-producing clostridia are responsible for antibiotic-associated pseudomembranous colitis.
J G Bartlett, and
T W Chang, and
M Gurwith, and
S L Gorbach, and
A B Onderdonk
June 1980,
Annals of internal medicine,
J G Bartlett, and
T W Chang, and
M Gurwith, and
S L Gorbach, and
A B Onderdonk
May 1981,
Journal of clinical pathology,
J G Bartlett, and
T W Chang, and
M Gurwith, and
S L Gorbach, and
A B Onderdonk
May 1985,
American family physician,
J G Bartlett, and
T W Chang, and
M Gurwith, and
S L Gorbach, and
A B Onderdonk
December 1981,
Hospital practice (Office ed.),
J G Bartlett, and
T W Chang, and
M Gurwith, and
S L Gorbach, and
A B Onderdonk
January 1977,
Canadian Medical Association journal,
J G Bartlett, and
T W Chang, and
M Gurwith, and
S L Gorbach, and
A B Onderdonk
May 1990,
American journal of diseases of children (1960),
J G Bartlett, and
T W Chang, and
M Gurwith, and
S L Gorbach, and
A B Onderdonk
September 1976,
CRC critical reviews in clinical radiology and nuclear medicine,
J G Bartlett, and
T W Chang, and
M Gurwith, and
S L Gorbach, and
A B Onderdonk
October 1979,
Missouri medicine,
J G Bartlett, and
T W Chang, and
M Gurwith, and
S L Gorbach, and
A B Onderdonk
May 1981,
Journal of the American Academy of Dermatology,
J G Bartlett, and
T W Chang, and
M Gurwith, and
S L Gorbach, and
A B Onderdonk
January 1980,
Acta gastro-enterologica Belgica,
