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Enzymic synthesis of 5-acetamido-9-azido-3,5,9-trideoxy-D-glycero-D-galacto-2-nonulosonic acid, a 9-azido-9-deoxy derivative of N-acetylneuraminic acid. 1980

R Brossmer, and U Rose, and D Kaspar, and T L Smith, and H Grasmuk, and F M Unger

UI MeSH Term Description Entries
D009345 Neisseria meningitidis A species of gram-negative, aerobic BACTERIA. It is a commensal and pathogen only of humans, and can be carried asymptomatically in the NASOPHARYNX. When found in cerebrospinal fluid it is the causative agent of cerebrospinal meningitis (MENINGITIS, MENINGOCOCCAL). It is also found in venereal discharges and blood. There are at least 13 serogroups based on antigenic differences in the capsular polysaccharides; the ones causing most meningitis infections being A, B, C, Y, and W-135. Each serogroup can be further classified by serotype, serosubtype, and immunotype. Diplokokkus intracellularis meningitidis,Meningococcus,Micrococcus intracellularis,Micrococcus meningitidis,Micrococcus meningitidis cerebrospinalis,Neisseria weichselbaumii
D009713 Nucleotidyltransferases A class of enzymes that transfers nucleotidyl residues. EC 2.7.7. Nucleotidyltransferase
D010728 Phosphoenolpyruvate A monocarboxylic acid anion derived from selective deprotonation of the carboxy group of phosphoenolpyruvic acid. It is a metabolic intermediate in GLYCOLYSIS; GLUCONEOGENESIS; and other pathways.
D004590 Electrophoresis, Paper Electrophoresis in which paper is used as the diffusion medium. This technique is confined almost entirely to separations of small molecules such as amino acids, peptides, and nucleotides, and relatively high voltages are nearly always used. Paper Electrophoresis
D000216 N-Acylneuraminate Cytidylyltransferase An enzyme that forms CMP-acylneuraminic acids, which donate the N-acylneuraminic acid residues to the terminal sugar residue of a ganglioside or glycoprotein. EC 2.7.7.43. Acylneuraminate Cytidylyltransferase,CMP Sialate Pyrophosphorylase,CMP Sialate Synthase,CMP-N-Acetylneuraminic Acid Synthetase,CMP-Sialic Acid Synthetase,Cytidine 5'-Monophosphosialic Acid Synthetase,Cytidine 5-Monophosphosialate Synthase,CMP N Acetylneuraminic Acid Synthetase,CMP Sialic Acid Synthetase,Cytidine 5 Monophosphosialate Synthase,Cytidine 5' Monophosphosialic Acid Synthetase,Cytidylyltransferase, Acylneuraminate,Cytidylyltransferase, N-Acylneuraminate,N Acylneuraminate Cytidylyltransferase,Pyrophosphorylase, CMP Sialate,Sialate Pyrophosphorylase, CMP,Sialate Synthase, CMP,Synthase, CMP Sialate,Synthase, Cytidine 5-Monophosphosialate,Synthetase, CMP-N-Acetylneuraminic Acid,Synthetase, CMP-Sialic Acid
D012794 Sialic Acids A group of naturally occurring N-and O-acyl derivatives of the deoxyamino sugar neuraminic acid. They are ubiquitously distributed in many tissues. N-Acetylneuraminic Acids,Acids, N-Acetylneuraminic,Acids, Sialic,N Acetylneuraminic Acids

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R Brossmer, and U Rose, and D Kaspar, and T L Smith, and H Grasmuk, and F M Unger
7,9-O-ethylidene and 7,9-O-benzylidene derivatives of 5-acetamido-3,5-dideoxy-D-glycero-D-galacto-nonulosonic acid (N-acetylneuraminic acid).
January 1971, Acta chemica Scandinavica,
R Brossmer, and U Rose, and D Kaspar, and T L Smith, and H Grasmuk, and F M Unger
Elimination of 2-keto-3-deoxy-D-glycero-D-galacto-nonulosonic acid 9-phosphate synthase activity from human N-acetylneuraminic acid 9-phosphate synthase by a single mutation.
July 2006, The Biochemical journal,
R Brossmer, and U Rose, and D Kaspar, and T L Smith, and H Grasmuk, and F M Unger
Synthesis of the nucleoside analogues of 3-deoxy-D-glycero-D-galacto-2-nonulosonic acid (KDN).
January 1991, Nucleic acids symposium series,
R Brossmer, and U Rose, and D Kaspar, and T L Smith, and H Grasmuk, and F M Unger
A novel sialidase capable of cleaving 3-deoxy-D-glycero-D-galacto-2-nonulosonic acid (KDN).
April 1994, Archives of biochemistry and biophysics,
R Brossmer, and U Rose, and D Kaspar, and T L Smith, and H Grasmuk, and F M Unger
Formal synthesis of (+)-3-deoxy-D-glycero-D-galacto-2-nonulosonic acid (KDN) via desymmetrization by ring-closing metathesis.
January 2001, Organic letters,
R Brossmer, and U Rose, and D Kaspar, and T L Smith, and H Grasmuk, and F M Unger
Replacement of the antifreeze-like domain of human N-acetylneuraminic acid phosphate synthase with the mouse antifreeze-like domain impacts both N-acetylneuraminic acid 9-phosphate synthase and 2-keto-3-deoxy-D-glycero-D-galacto-nonulosonic acid 9-phosphate synthase activities.
January 2008, BMB reports,
R Brossmer, and U Rose, and D Kaspar, and T L Smith, and H Grasmuk, and F M Unger
Catalysis by a new sialidase, deaminoneuraminic acid residue-cleaving enzyme (KDNase Sm), initially forms a less stable alpha-anomer of 3-deoxy-D-glycero-D-galacto-nonulosonic acid and is strongly inhibited by the transition state analogue, 2-deoxy-2, 3-didehydro-D-glycero-D-galacto-2-nonulopyranosonic acid, but not by 2-deoxy-2,3-didehydro-N-acetylneuraminic acid.
February 1997, The Journal of biological chemistry,
R Brossmer, and U Rose, and D Kaspar, and T L Smith, and H Grasmuk, and F M Unger
Distinguishing mammalian sialidases by inhibition kinetics with novel derivatives of 5-acetamido-2,6-anhydro-3,5-dideoxy-D-glycero-D-galacto-non-2-enonic acid, an unsaturated derivative of N-acetylneuraminic acid.
August 1991, Carbohydrate research,
R Brossmer, and U Rose, and D Kaspar, and T L Smith, and H Grasmuk, and F M Unger
Phase-transfer-catalyzed synthesis of a phenylseleno alpha-ketoside of N-acetylneuraminic acid, (phenyl 5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-2- selenononulopyranosid)onic acid; a new sialidase inhibitor.
December 1990, Carbohydrate research,
R Brossmer, and U Rose, and D Kaspar, and T L Smith, and H Grasmuk, and F M Unger
[Synthesis of O-(5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-2- nonulo-pyranosyluronic)-(2----3)-O-beta-D-galactopyrano sylp61 ----3)-2-acetamido-2-deoxy-D-galactopyranose].
April 1988, Carbohydrate research,
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