Biomaterial Database

[Adrenal cortex function in trophoblastic disease]. 1980

T V El'chits

In 100 patients with trophoblastic tumors the functional activity of the adrenal cortex was examined before and after chemotherapy. Androgen-producing function of the adrenal cortex was found to be reduced as well as the absolute number of excreted 17-ketosteroids separate fractions and their ratio. The glucocorticoid function of the adrenal cortex shows a monotonous character. Only in patients having uterine chorion-epithelioma with metastases a reliable reduction of the fraction of 11-hydroxy-17-ketosteroids is noted before and after chemotherapy, while the per cent content of free 17-oxy-corticoid fraction is increased with regard to their total amount. Successful chemotherapy, associated with a lower titre of chorionic gonadotropins up to its complete disappearance, does not result in normalization of values characterizing the functional activity of the adrenal cortex.

UI	MeSH Term	Description	Entries
D008875	Middle Aged	An adult aged 45 - 64 years.	Middle Age
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D002940	Circadian Rhythm	The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs or environmental and physiological stimuli.	Diurnal Rhythm,Nyctohemeral Rhythm,Twenty-Four Hour Rhythm,Nycthemeral Rhythm,Circadian Rhythms,Diurnal Rhythms,Nycthemeral Rhythms,Nyctohemeral Rhythms,Rhythm, Circadian,Rhythm, Diurnal,Rhythm, Nycthemeral,Rhythm, Nyctohemeral,Rhythm, Twenty-Four Hour,Rhythms, Circadian,Rhythms, Diurnal,Rhythms, Nycthemeral,Rhythms, Nyctohemeral,Rhythms, Twenty-Four Hour,Twenty Four Hour Rhythm,Twenty-Four Hour Rhythms
D005260	Female		Females
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293	Adolescent	A person 13 to 18 years of age.	Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000302	Adrenal Cortex	The outer layer of the adrenal gland. It is derived from MESODERM and comprised of three zones (outer ZONA GLOMERULOSA, middle ZONA FASCICULATA, and inner ZONA RETICULARIS) with each producing various steroids preferentially, such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and ANDROSTENEDIONE. Adrenal cortex function is regulated by pituitary ADRENOCORTICOTROPIN.	Cortex, Adrenal
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D014328	Trophoblastic Neoplasms	Trophoblastic growth, which may be gestational or nongestational in origin. Trophoblastic neoplasia resulting from pregnancy is often described as gestational trophoblastic disease to distinguish it from germ cell tumors which frequently show trophoblastic elements, and from the trophoblastic differentiation which sometimes occurs in a wide variety of epithelial cancers. Gestational trophoblastic growth has several forms, including HYDATIDIFORM MOLE and CHORIOCARCINOMA. (From Holland et al., Cancer Medicine, 3d ed, p1691)	Trophoblastic Cancer,Trophoblastic Tumor,Neoplasms, Trophoblastic,Trophoblast Cancer,Trophoblast Neoplasms,Trophoblast Tumor,Cancer, Trophoblast,Cancer, Trophoblastic,Cancers, Trophoblast,Cancers, Trophoblastic,Neoplasm, Trophoblast,Neoplasm, Trophoblastic,Neoplasms, Trophoblast,Trophoblast Cancers,Trophoblast Neoplasm,Trophoblast Tumors,Trophoblastic Cancers,Trophoblastic Neoplasm,Trophoblastic Tumors,Tumor, Trophoblast,Tumor, Trophoblastic,Tumors, Trophoblast,Tumors, Trophoblastic
D014594	Uterine Neoplasms	Tumors or cancer of the UTERUS.	Cancer of Uterus,Uterine Cancer,Cancer of the Uterus,Neoplasms, Uterine,Neoplasms, Uterus,Uterus Cancer,Uterus Neoplasms,Cancer, Uterine,Cancer, Uterus,Cancers, Uterine,Cancers, Uterus,Neoplasm, Uterine,Neoplasm, Uterus,Uterine Cancers,Uterine Neoplasm,Uterus Cancers,Uterus Neoplasm