-transparent.png){kind=logo}
The effects of metopimazine on gastric, jejunal and colonic motility were recently described. The purpose of this study is to evaluate the action of a bolus injection of metopimazine (10 mg IV) on lower esophageal sphincter pressure with continuously perfused catheters. Significative increase (p less than 0,05) of lower esophageal sphincter pressure is always observed in 10 normal subjects and 5 patients with symptomatic gastro-esophageal reflux. The rate of lower esophageal sphincter pressure increase is significantly (p less than 0,05) more important in the symptomatic patients (160 +/- 19) than in controls (134 +/- 20). Further clinical study will be required to confirm these first data before proposing metopimazine as treatment of lower esophageal sphincter incompetence with gastro-oesophageal reflux.
A Gosselin, and
M Gosselin, and
J F Bretagne
December 1979,
Nihon Heikatsukin Gakkai zasshi,
A Gosselin, and
M Gosselin, and
J F Bretagne
December 1980,
Nihon Heikatsukin Gakkai zasshi,
A Gosselin, and
M Gosselin, and
J F Bretagne
March 1982,
Gastroenterologie clinique et biologique,
A Gosselin, and
M Gosselin, and
J F Bretagne
September 1977,
Nihon Heikatsukin Gakkai zasshi,
A Gosselin, and
M Gosselin, and
J F Bretagne
August 1979,
Zeitschrift fur Gastroenterologie,
A Gosselin, and
M Gosselin, and
J F Bretagne
January 1995,
Surgery annual,
A Gosselin, and
M Gosselin, and
J F Bretagne
January 1982,
Chirurgie pediatrique,
A Gosselin, and
M Gosselin, and
J F Bretagne
July 1989,
Digestive diseases and sciences,
A Gosselin, and
M Gosselin, and
J F Bretagne
September 1978,
Minerva chirurgica,
A Gosselin, and
M Gosselin, and
J F Bretagne
November 1974,
Revista medica de Chile,
