-transparent.png){kind=logo}
1. The metabolism of a number of xenobiotics has been investigated in isolated viable rat hepatocytes and kidney tubule fragments in suspension. 2. The level of Phase I metabolism was very low in the kidney cells although such cells possess appreciable Phase II metabolic capacity. 3. These findings are discussed in relation to the physiological role of cytochrome P-450 and the conjugating enzymes, and the value of intact cells systems in assessing inter-organ differences in xenobiotic metabolism.
Related Publications
J R Fry, and
P Wiebkin, and
J Kao, and
C A Jones, and
J Gwynn, and
J W Bridges
January 1984,
Drug metabolism and disposition: the biological fate of chemicals,
J R Fry, and
P Wiebkin, and
J Kao, and
C A Jones, and
J Gwynn, and
J W Bridges
April 1979,
The Journal of clinical investigation,
J R Fry, and
P Wiebkin, and
J Kao, and
C A Jones, and
J Gwynn, and
J W Bridges
July 1987,
Biochimica et biophysica acta,
J R Fry, and
P Wiebkin, and
J Kao, and
C A Jones, and
J Gwynn, and
J W Bridges
March 2007,
Toxicology in vitro : an international journal published in association with BIBRA,
J R Fry, and
P Wiebkin, and
J Kao, and
C A Jones, and
J Gwynn, and
J W Bridges
January 1976,
Current problems in clinical biochemistry,
J R Fry, and
P Wiebkin, and
J Kao, and
C A Jones, and
J Gwynn, and
J W Bridges
September 1978,
Life sciences,
J R Fry, and
P Wiebkin, and
J Kao, and
C A Jones, and
J Gwynn, and
J W Bridges
September 1988,
Kidney international. Supplement,
J R Fry, and
P Wiebkin, and
J Kao, and
C A Jones, and
J Gwynn, and
J W Bridges
February 1986,
Journal of pharmacological methods,
J R Fry, and
P Wiebkin, and
J Kao, and
C A Jones, and
J Gwynn, and
J W Bridges
April 1994,
Cell biology and toxicology,
J R Fry, and
P Wiebkin, and
J Kao, and
C A Jones, and
J Gwynn, and
J W Bridges
November 1990,
In vitro cellular & developmental biology : journal of the Tissue Culture Association,
