-transparent.png){kind=logo}
Homogenates of human endometrial, myometrial and leiomyoma tissues were incubated with (2,4,6,7-3H)-estradiol and tritiated catechol estrogens were isolated and identified. Though 2- and 4-hydroxylations were about the same in endometrium, 4-hydroxylation was two to four fold higher than 2-hydroxylation in myometrium and leiomyoma. However, endometrium showed greater capacity to form both 2- and 4-hydroxyestrogens than the other two tissues. Both 2- and 4-hydroxylations were significantly less than in myometrium. In view of the reports indicating that inhibitors of catechol 0-methyl transferase (COMT) might act as antineoplastic agents due to their interference with t-RNA methylases and since catechol estrogens inhibit COMT, the present results suggest that endogenous synthesis of catechol estrogens may play an important role in the pathophysiology of uterine leiomyoma.
V V Reddy, and
P Hanjani, and
R Rajan
April 2006,
Nihon rinsho. Japanese journal of clinical medicine,
V V Reddy, and
P Hanjani, and
R Rajan
January 1998,
Biochemical pharmacology,
V V Reddy, and
P Hanjani, and
R Rajan
May 1996,
Steroids,
V V Reddy, and
P Hanjani, and
R Rajan
September 1981,
Science (New York, N.Y.),
V V Reddy, and
P Hanjani, and
R Rajan
September 1980,
South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde,
V V Reddy, and
P Hanjani, and
R Rajan
November 1984,
Nihon rinsho. Japanese journal of clinical medicine,
V V Reddy, and
P Hanjani, and
R Rajan
February 1990,
Journal of steroid biochemistry,
V V Reddy, and
P Hanjani, and
R Rajan
April 1972,
The Journal of clinical endocrinology and metabolism,
V V Reddy, and
P Hanjani, and
R Rajan
May 1983,
Fertility and sterility,
