-transparent.png){kind=logo}
BK virus (BKV)-transformed cells and BKV-induced tumors as well as in vitro derived tumor cell lines were all found to contain BKV DNA sequences when analysed by DNA-DNA reassociation kinetics. In transformed cells the number of viral genome equivalents per diploid cell genome (CG divided by VG) decreased with increasing generations. Likewise, single cell clones had a lower CG divided by VG than parental transformed cells. BKV-induced tumors had a high CG divided by VG. Tumor cells cultivated in vitro and their clones had a lower CG divided by VG than BKV-induced tumors from which they were derived, suggesting a multiclonal origin of tumors. Hamster tumors induced by subcutaneous inoculation of BKV-transformed cells or tumor cell lines had a higher CG divided by VG than cells producing them. Variation in CG divided by VG is discussed in terms of cell selection depending on different in vitro or in vivo conditions of cell growth. In some cases, however, the decrease in CG divided by VG most likely depends on loss on free viral sequences from transformed cells or tumors.
M P Grossi, and
A Corallini, and
F Poli, and
A Valieri, and
G Milanesi, and
G Barbanti-Brodano
May 1980,
Virology,
M P Grossi, and
A Corallini, and
F Poli, and
A Valieri, and
G Milanesi, and
G Barbanti-Brodano
January 1983,
Progress in clinical and biological research,
M P Grossi, and
A Corallini, and
F Poli, and
A Valieri, and
G Milanesi, and
G Barbanti-Brodano
October 1978,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
M P Grossi, and
A Corallini, and
F Poli, and
A Valieri, and
G Milanesi, and
G Barbanti-Brodano
December 1973,
Virology,
M P Grossi, and
A Corallini, and
F Poli, and
A Valieri, and
G Milanesi, and
G Barbanti-Brodano
March 1974,
Chromosoma,
M P Grossi, and
A Corallini, and
F Poli, and
A Valieri, and
G Milanesi, and
G Barbanti-Brodano
December 1978,
Biochimica et biophysica acta,
M P Grossi, and
A Corallini, and
F Poli, and
A Valieri, and
G Milanesi, and
G Barbanti-Brodano
February 1977,
Biochemical and biophysical research communications,
M P Grossi, and
A Corallini, and
F Poli, and
A Valieri, and
G Milanesi, and
G Barbanti-Brodano
April 1989,
Virus research,
M P Grossi, and
A Corallini, and
F Poli, and
A Valieri, and
G Milanesi, and
G Barbanti-Brodano
July 1973,
Biochemical genetics,
M P Grossi, and
A Corallini, and
F Poli, and
A Valieri, and
G Milanesi, and
G Barbanti-Brodano
June 1966,
Cancer research,
