BIOMAT Database Logo BIOMAT Database Logo

[Treatment of whooping cough and whooping cough syndrome by cefoperazone (author's transl)]. 1980

T Motohiro, and Y Sakata, and T Fujimoto, and T Nishiyama, and T Nakajima, and K Ishimoto, and K Tominaga, and F Yamashita, and H Shishido, and K Watanabe, and K Matsumoto, and K Tazaki, and S Oki, and H Araki, and N Takajo, and K Yuasa, and Y Tanaka, and S Tsugawa, and K Nagayama, and R Komatsu, and M Yamamoto, and R Ookita, and Y Sakaguchi, and K Terasawa, and M Kinoshita

Clinical trial of cefoperazone (CPZ) for the treatment of whooping cough and whooping cough syndrome was performed and the following results were obtained. 1) In 18 cases suffering from whooping cough, CPZ was given 47 approximately 106 mg/kg/day (average 72 mg/kg/day) by intravenous route. The clinical efficacy rates judged by doctors in charge were 44% on the 3 rd day, 75% on the 7 th day, 86% on the period day. And in these cases, the clinical efficacy rates judged by committee members were 56%, 83% and 86%. 2) In 6 cases diagnosed as whooping cough syndrome, CPZ was given 49 approximately 96 mg/kg/day (average 59 mg/kg/day) by the same route. The clinical efficacy rates judged by doctors in charge were 67% on the 3 rd day, 80% on the 7 th day and 75% on the period day. And in these cases, those judged by committee members were 83%, 80% and 100%. 3) In 1 case, Bordetella pertussis was searched and showed 0.012 mcg/ml of MIC. It was eliminated on the 1 st day after administration. 4) Doctors in charge judged the utility of CPZ for whooping cough. Twelve cases were useful and 6 cases were slightly useful. 5) No side effects were observed except for elevation of GOT and LDH. These results suggest that CPZ might be useful drug against whooping cough.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D007275 Injections, Intravenous Injections made into a vein for therapeutic or experimental purposes. Intravenous Injections,Injection, Intravenous,Intravenous Injection
D008297 Male Males
D001886 Bordetella pertussis A species of gram-negative, aerobic bacteria that is the causative agent of WHOOPING COUGH. Its cells are minute coccobacilli that are surrounded by a slime sheath. Bacterium tussis-convulsivae,Haemophilus pertussis,Hemophilus pertussis
D002438 Cefoperazone Semisynthetic broad-spectrum cephalosporin with a tetrazolyl moiety that is resistant to beta-lactamase. It may be used to treat Pseudomonas infections. Cefobid,Cefoperazon,Cefoperazone Sodium,Cefoperazone Sodium Salt,Céfobis,T-1551,T1551,Salt, Cefoperazone Sodium,Sodium Salt, Cefoperazone,Sodium, Cefoperazone,T 1551
D002511 Cephalosporins A group of broad-spectrum antibiotics first isolated from the Mediterranean fungus ACREMONIUM. They contain the beta-lactam moiety thia-azabicyclo-octenecarboxylic acid also called 7-aminocephalosporanic acid. Antibiotics, Cephalosporin,Cephalosporanic Acid,Cephalosporin,Cephalosporin Antibiotic,Cephalosporanic Acids,Acid, Cephalosporanic,Acids, Cephalosporanic,Antibiotic, Cephalosporin,Cephalosporin Antibiotics
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D004341 Drug Evaluation Any process by which toxicity, metabolism, absorption, elimination, preferred route of administration, safe dosage range, etc., for a drug or group of drugs is determined through clinical assessment in humans or veterinary animals. Evaluation Studies, Drug,Drug Evaluation Studies,Drug Evaluation Study,Drug Evaluations,Evaluation Study, Drug,Evaluation, Drug,Evaluations, Drug,Studies, Drug Evaluation,Study, Drug Evaluation

Related Publications

T Motohiro, and Y Sakata, and T Fujimoto, and T Nishiyama, and T Nakajima, and K Ishimoto, and K Tominaga, and F Yamashita, and H Shishido, and K Watanabe, and K Matsumoto, and K Tazaki, and S Oki, and H Araki, and N Takajo, and K Yuasa, and Y Tanaka, and S Tsugawa, and K Nagayama, and R Komatsu, and M Yamamoto, and R Ookita, and Y Sakaguchi, and K Terasawa, and M Kinoshita
[The controversy concerning whooping cough vaccination (author's transl)].
January 1978, La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris,
T Motohiro, and Y Sakata, and T Fujimoto, and T Nishiyama, and T Nakajima, and K Ishimoto, and K Tominaga, and F Yamashita, and H Shishido, and K Watanabe, and K Matsumoto, and K Tazaki, and S Oki, and H Araki, and N Takajo, and K Yuasa, and Y Tanaka, and S Tsugawa, and K Nagayama, and R Komatsu, and M Yamamoto, and R Ookita, and Y Sakaguchi, and K Terasawa, and M Kinoshita
[Neurological complications following whooping-cough vaccination (author's transl)].
November 1977, Monatsschrift fur Kinderheilkunde,
T Motohiro, and Y Sakata, and T Fujimoto, and T Nishiyama, and T Nakajima, and K Ishimoto, and K Tominaga, and F Yamashita, and H Shishido, and K Watanabe, and K Matsumoto, and K Tazaki, and S Oki, and H Araki, and N Takajo, and K Yuasa, and Y Tanaka, and S Tsugawa, and K Nagayama, and R Komatsu, and M Yamamoto, and R Ookita, and Y Sakaguchi, and K Terasawa, and M Kinoshita
[Preventive treatment of whooping cough by anti-whooping cough globulins].
January 1958, Pediatrie,
T Motohiro, and Y Sakata, and T Fujimoto, and T Nishiyama, and T Nakajima, and K Ishimoto, and K Tominaga, and F Yamashita, and H Shishido, and K Watanabe, and K Matsumoto, and K Tazaki, and S Oki, and H Araki, and N Takajo, and K Yuasa, and Y Tanaka, and S Tsugawa, and K Nagayama, and R Komatsu, and M Yamamoto, and R Ookita, and Y Sakaguchi, and K Terasawa, and M Kinoshita
[Treatment of pertussis with cefoperazone (author's transl)].
September 1980, The Japanese journal of antibiotics,
T Motohiro, and Y Sakata, and T Fujimoto, and T Nishiyama, and T Nakajima, and K Ishimoto, and K Tominaga, and F Yamashita, and H Shishido, and K Watanabe, and K Matsumoto, and K Tazaki, and S Oki, and H Araki, and N Takajo, and K Yuasa, and Y Tanaka, and S Tsugawa, and K Nagayama, and R Komatsu, and M Yamamoto, and R Ookita, and Y Sakaguchi, and K Terasawa, and M Kinoshita
Treatment of Whooping Cough by Atropia.
March 1880, Buffalo medical and surgical journal,
T Motohiro, and Y Sakata, and T Fujimoto, and T Nishiyama, and T Nakajima, and K Ishimoto, and K Tominaga, and F Yamashita, and H Shishido, and K Watanabe, and K Matsumoto, and K Tazaki, and S Oki, and H Araki, and N Takajo, and K Yuasa, and Y Tanaka, and S Tsugawa, and K Nagayama, and R Komatsu, and M Yamamoto, and R Ookita, and Y Sakaguchi, and K Terasawa, and M Kinoshita
[Treatment of whooping cough by ozone].
November 1956, Revista brasileira de medicina,
T Motohiro, and Y Sakata, and T Fujimoto, and T Nishiyama, and T Nakajima, and K Ishimoto, and K Tominaga, and F Yamashita, and H Shishido, and K Watanabe, and K Matsumoto, and K Tazaki, and S Oki, and H Araki, and N Takajo, and K Yuasa, and Y Tanaka, and S Tsugawa, and K Nagayama, and R Komatsu, and M Yamamoto, and R Ookita, and Y Sakaguchi, and K Terasawa, and M Kinoshita
Treatment of whooping cough by vaccination.
January 1947, Medizinische Klinik,
T Motohiro, and Y Sakata, and T Fujimoto, and T Nishiyama, and T Nakajima, and K Ishimoto, and K Tominaga, and F Yamashita, and H Shishido, and K Watanabe, and K Matsumoto, and K Tazaki, and S Oki, and H Araki, and N Takajo, and K Yuasa, and Y Tanaka, and S Tsugawa, and K Nagayama, and R Komatsu, and M Yamamoto, and R Ookita, and Y Sakaguchi, and K Terasawa, and M Kinoshita
[Treatment of whooping cough by rovamycin].
January 1959, Archives francaises de pediatrie,
T Motohiro, and Y Sakata, and T Fujimoto, and T Nishiyama, and T Nakajima, and K Ishimoto, and K Tominaga, and F Yamashita, and H Shishido, and K Watanabe, and K Matsumoto, and K Tazaki, and S Oki, and H Araki, and N Takajo, and K Yuasa, and Y Tanaka, and S Tsugawa, and K Nagayama, and R Komatsu, and M Yamamoto, and R Ookita, and Y Sakaguchi, and K Terasawa, and M Kinoshita
Treatment of whooping cough by bismuth.
June 1948, El Dia medico,
T Motohiro, and Y Sakata, and T Fujimoto, and T Nishiyama, and T Nakajima, and K Ishimoto, and K Tominaga, and F Yamashita, and H Shishido, and K Watanabe, and K Matsumoto, and K Tazaki, and S Oki, and H Araki, and N Takajo, and K Yuasa, and Y Tanaka, and S Tsugawa, and K Nagayama, and R Komatsu, and M Yamamoto, and R Ookita, and Y Sakaguchi, and K Terasawa, and M Kinoshita
Whooping cough treatment.
February 1946, Journal de medecine de Lyon,
Copied contents to your clipboard!