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Adrenal function was assessed in dogs after intramuscular administration of a single dose of methylprednisolone acetate (MPA). Twelve dogs were test challenged with adrenocorticotropic hormone (ACTH) and then assigned randomly to 1 of 3 groups and given MPA. Individual groups were test challenged with ACTH 2, 3, or 4 weeks later. All dogs were rechallenged 5 weeks after MPA administration. Plasma cortisol concentration was determined by radioimmunoassay. Basal plasma cortisol (time 0) was depressed on weeks 2 and 3, but not on weeks 4 and 5. Adrenal response to ACTH (increment of cortisol change) was suppressed on weeks 2, 4, and 5, but not on week 3. It was concluded that a single dose of MPA is capable of altering adrenal cortical function in dogs for at least 5 weeks.
R J Kemppainen, and
M D Lorenz, and
F N Thompson
November 2017,
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R J Kemppainen, and
M D Lorenz, and
F N Thompson
September 1981,
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R J Kemppainen, and
M D Lorenz, and
F N Thompson
September 1981,
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R J Kemppainen, and
M D Lorenz, and
F N Thompson
October 2006,
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R J Kemppainen, and
M D Lorenz, and
F N Thompson
March 2018,
Pain physician,
R J Kemppainen, and
M D Lorenz, and
F N Thompson
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R J Kemppainen, and
M D Lorenz, and
F N Thompson
December 1981,
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R J Kemppainen, and
M D Lorenz, and
F N Thompson
May 1982,
Research in veterinary science,
R J Kemppainen, and
M D Lorenz, and
F N Thompson
May 2018,
Pain physician,
R J Kemppainen, and
M D Lorenz, and
F N Thompson
March 1986,
The Journal of pharmacology and experimental therapeutics,
