Biomaterial Database

Evaluation of chemical disinfectants for aleutian disease virus of mink. 1981

D T Shen, and L W Leendertsen, and J R Gorham

Nine chemicals and commercial disinfectants were tested for inactivation of Aleutian disease virus of mink. In the presence of distilled water, a commercial disinfectant (O-Syl), halogen derivatives (iodophor and sodium hypochlorite), and glutaraldehyde (2.0%) inactivated 4 log10 (based on 0.25 ml) of the virus within 10 minutes at 23 C. Formalin (2.0%) and O-Syl were slower to inactivate the virus, but achieved a 4 log10 reduction in titer by 30 minutes' contact time. In the presence of 10% bovine serum, formalin (1.0%), O-Syl, and sodium hydroxide (0.5%) achieved a 4 log10 reduction within 10 minutes. All agents tested had some virucidal effect.

UI	MeSH Term	Description	Entries
D007466	Iodophors	Complexes of iodine and non-ionic SURFACE-ACTIVE AGENTS acting as carrier and solubilizing agent for the iodine in water. Iodophors usually enhance bactericidal activity of iodine, reduce vapor pressure and odor, minimize staining, and allow wide dilution with water. (From Merck Index, 11th ed)	Tamed Iodine,Iodine, Tamed
D002710	Chlorhexidine	A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque.	Chlorhexidine Acetate,Chlorhexidine Hydrochloride,MK-412A,Novalsan,Sebidin A,Tubulicid,Acetate, Chlorhexidine,Hydrochloride, Chlorhexidine,MK 412A,MK412A
D004202	Disinfectants	Substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity. Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (From Hawley's Condensed Chemical Dictionary, 11th ed)	Biocide,Disinfectant,Biocides
D005557	Formaldehyde	A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717)	Formalin,Formol,Methanal,Oxomethane
D005976	Glutaral	One of the protein CROSS-LINKING REAGENTS that is used as a disinfectant for sterilization of heat-sensitive equipment and as a laboratory reagent, especially as a fixative.	Glutaraldehyde,Cidex,Diswart,Gludesin,Glutardialdehyde,Glutarol,Korsolex,Novaruca,Sekumatic,Sonacide,Sporicidin
D000431	Ethanol	A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.	Alcohol, Ethyl,Absolute Alcohol,Grain Alcohol,Alcohol, Absolute,Alcohol, Grain,Ethyl Alcohol
D000454	Aleutian Mink Disease Virus	A species of PARVOVIRUS that causes a disease in mink, mainly those homozygous for the recessive Aleutian gene which determines a desirable coat color.	Aleutian Disease Virus,Aleutian Mink Disease Parvovirus
D012972	Sodium Hydroxide	A highly caustic substance that is used to neutralize acids and make sodium salts. (From Merck Index, 11th ed)	Caustic Soda,Hydroxide, Sodium,Soda, Caustic
D012973	Sodium Hypochlorite	It is used as an oxidizing and bleaching agent and as a disinfectant. (From Grant & Hackh's Chemical Dictionary, 5th ed)	Antiformin,Clorox,Sodium Hypochlorite (Solution),Hypochlorite, Sodium
D014713	Viruses, Unclassified	Viruses whose taxonomic relationships have not been established.	Unclassified Virus,Unclassified Viruses